53727-45-0Relevant academic research and scientific papers
One-step cyclization: Synthesis of N -heteroalkyl-N′-tosylpiperazines
Huang, Jianying,Xu, Weiyuan,Xie, Hujun,Li, Shijun
, p. 7506 - 7511 (2012/10/29)
Piperazine derivatives are important intermediates in organic synthesis and useful building blocks in pharmaceutical and fine chemical industries. Currently available synthetic routes for these heterocyclic compounds have limited scope owing to the harsh reaction conditions, low yields, and multistep process. Herein, we reported a practical method for synthesis of alkyl-, alcohol-, amine-, and ester-extended tosylpiperazines under mild conditions with moderate to high yields. This protocol exhibits potential applicability in the synthesis of pharmaceuticals and natural products because of the operational simplicity and the conveniently available reactants. On the basis of the experimental and theoretical results, a plausible mechanism of aliphatic nucleophilic substitution (SN) in the cyclization has been postulated and evidence for the formation of a six-membered ring has also been confirmed by means of density functional theory (DFT) calculations.
Oligoethylenepiperazines
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, (2008/06/13)
Oligoethylenepiperazines and their derivatives of the formula SPC1 Wherein n is a positive integer of 1 to 7 inclusive; m is zero or one when n=1, or m is one when n=2?7 R1 is hydrogen, benzenesulfonyl or benzenesulfonyl ring substituted by at least one member selected from the group consisting of lower alkyl of 1-4 carbon atoms, nitro and amino; R2 is halogen when m=zero and hydrogen, benzenesulfonyl or benzenesulfonyl ring substituted by at least one member selected from the group consisting of lower alkyl of 1-4 carbon atoms, nitro and amino when m=one; and the cationic salts thereof are useful as anion exchange oligomers, antihelmintic compounds, and intermediates for the preparation of polymers and fine industrial chemicals.
