53731-99-0

Basic information

• Product Name: 5-CHLORO-2-METHYLBENZAMIDE
• Synonyms: 5-CHLORO-2-METHYLBENZAMIDE;(R)-alpha-Bromo-alpha-(4-chloro-phenyl)acetonitrile;(R)-Bromo-(4-chloro-phenyl)-acetonitrile;Benzeneacetonitrile, .alpha.-broMo-4-chloro-;2-Bromo-2-(4-chlorophenyl)acetonitrile
• CAS NO: 53731-99-0
• Molecular Formula: C₈H₅BrClN
• Molecular Weight: 230.49
• Mol File: 53731-99-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-CHLORO-2-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-METHYLBENZAMIDE(53731-99-0)
• EPA Substance Registry System: 5-CHLORO-2-METHYLBENZAMIDE(53731-99-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 53731-99-0(Hazardous Substances Data)

Usage

General Description

5-CHLORO-2-METHYLBENZAMIDE is a chemical compound with the molecular formula C8H8ClNO. It is an amide derivative of 2-methylbenzoic acid, featuring a chloro substitution at the 5 position. 5-CHLORO-2-METHYLBENZAMIDE is commonly used in organic synthesis and pharmaceutical research as a building block for creating other organic compounds and pharmaceutical drugs. It is also utilized in the production of agrochemicals and veterinary drugs. 5-CHLORO-2-METHYLBENZAMIDE is known for its potential as an intermediate in the synthesis of various biologically active compounds and is a versatile chemical with a wide range of applications in synthetic chemistry.

Upstream product

• 13312-83-9 4-chloromandelonitrile 
• 140-53-4 p-chlorobenzyl cyanide 

Downstream Products

• 107106-60-5 3-(4-chloro-α-cyanobenzylthio)propionic acid 
• 174574-58-4 2-Amino-benzoic acid (4-chloro-phenyl)-cyano-methyl ester 
• 1391013-16-3 N-(4-amino-3,5-bis-(4-chloro-phenyl)-3H-thiazol-2-ylidine)-benzamine 
• 1391013-17-4 N-(4-amino-5-(4-chloro-phenyl)-3-phenyl-3H-thiazol-2-ylidine)-benzamide 
• 1391013-18-5 N-(3-allyl-4-amino-5-(4-chloro-phenyl)-3H-thiazol-2-ylidine)-4-methyl-benzamide 
• 1351802-91-9 2,5-bis(4-chlorophenyl)-1,3-thiazol-4-amine 
• 1351802-90-8 5-(4-chlorophenyl)-2-phenyl-1,3-thiazol-4-amine 
• 4578-80-7 2-(p-Chlorophenyl)-2-phenylacetonitrile 
• 50872-42-9 (3-trifluoromethylphenoxy)-(4-chlorophenyl)acetonitrile 
• 88875-62-1 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester 
• 88875-70-1 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 
• 21771-88-0 α-(4-chlorophenyl)phenylacetic acid 
• 174574-63-1 C₁₈H₁₃Cl₂N₃O₄ 
• 219487-89-5 C₂₅H₂₀Cl₂N₄O₃ 

Relevant articles and documents

Enantioselective Mannich-Type Reactions to Construct Trifluoromethylthio-Containing Tetrasubstituted Carbon Stereocenters via Asymmetric Dual-Reagent Catalysis

An approach to construct tetrasubstituted carbon stereocenters bearing both a trifluoromethylthio (SCF3) group and a cyano group has been realized, through asymmetric organophosphine-catalyzed Mannich-type reactions. The products were obtained

PHARMACEUTICAL COMPOUNDS

Compounds of the formula (I), and salts, solvates, tautomers and N-oxide thereof; wherein TG is selected from groups (1) and (2): wherein the asterisk (*) represents the point of attachment of the group E to the group X; Rla is an optionally substituted aryl or heteroaryl group; Rlb is hydrogen or a group Rla; X is an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 are heteroatoms selected from O, N and S; and A, E, R2, R3, R4, Q1 and Q2 are as defined in the claims; provided that when E is aryl or heteroaryl, then Q2 is other than a bond; and further provided that the moiety (a) is other than a group (BG1) or (BG2); wherein (BGl) and (BG2) are each optionally substituted; T is N or CRZ; J1-J2 is selected from N=C(RZ), (RZ)C=N, (RZ)N-C(O), (RZ)2C-C(O), N=N and (RZ)C=C(R6); J4 -J3 is a group N=C(RZ) or a group (RZ)N-CO; and RZ is hydrogen or a substituent. The compounds of the formula (I) have PKA and PKB kinase inhibiting activity and are useful in the treatment of cancers.

A synthetic route to [1,2,4]triazolo[1,5-a][4,1]benzoxazepines

A reaction sequence leading to the new title compounds is described, the key step of which is an intramolecular cycloaddition of nitrilimine to a nitrile group.