4578-80-7

Basic information

• Product Name: 2-(p-Chlorophenyl)-2-phenylacetonitrile
• Synonyms: 2-(p-Chlorophenyl)-2-phenylacetonitrile
• CAS NO: 4578-80-7
• Molecular Weight: 227.693
• Mol File: 4578-80-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-(p-Chlorophenyl)-2-phenylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(p-Chlorophenyl)-2-phenylacetonitrile(4578-80-7)
• EPA Substance Registry System: 2-(p-Chlorophenyl)-2-phenylacetonitrile(4578-80-7)

Safety Data

• Hazardous Substances Data: 4578-80-7(Hazardous Substances Data)

Usage

Type of compound

Nitrile derivative of acetophenone

Common uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Physical state

Pale yellow solid at room temperature

Solubility

Insoluble in water, soluble in organic solvents

Potential applications

Precursor in manufacturing other organic compounds, building block in synthesis of complex molecules

Field of importance

Organic chemistry

Upstream product

• 119-56-2 (4-chlorophenyl)phenylmethanol 
• 106-39-8 bromochlorobenzene 
• 140-29-4 phenylacetonitrile 
• 1010720-50-9 1-chloro-4-(2,2-difluoro-1-phenylvinyl)benzene 
• 7677-24-9 trimethylsilyl cyanide 
• 86409-62-3 tricarbonyl(1,4-dichlorobenzene)chromium⁽⁰⁾ 
• 53731-99-0 2-bromo-2-(4-chlorophenyl)acetonitrile 
• 532-28-5 (RS)-mandelonitrile 
• 140-53-4 p-chlorobenzyl cyanide 
• 134-85-0 4-chlorobenzophenone 
• 134-83-8 1-chloro-4-(chloro(phenyl)methyl)benzene 
• 108-90-7 chlorobenzene 
• 5798-79-8 bromo-phenyl-acetonitrile 
• 71-43-2 benzene 

Downstream Products

• 324008-33-5 2-(2-{2-[(4-chloro-phenyl)-phenyl-methyl]-thiazol-4-yl}-ethyl)-isoindole-1,3-dione 
• 51355-14-7 4-bromo-2-phenyl-2-(4-chlorophenyl)butyronitrile 
• 882979-07-9 4-methylpiperazine-1-carbodithioic acid 3-cyano-3-phenyl-3-(4-chlorophenyl)propyl ester 
• 1247026-26-1 C₂₈H₁₈Cl₂N₂ 
• 108240-27-3 diethyl-[2-(4-chloro-phenyl)-2-phenyl-ethyl]-amine 
• 101436-43-5 ethyl-[2-(4-chloro-phenyl)-2-phenyl-ethyl]-amine 
• 107153-92-4 [2-(4-chloro-phenyl)-2-phenyl-ethyl]-methyl-amine 
• 88875-62-1 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester 
• 88875-70-1 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 
• 134-85-0 4-chlorobenzophenone 
• 21771-88-0 α-(4-chlorophenyl)phenylacetic acid 
• 22187-46-8 (p-Chlor-phenyl)-phenyl-thioacetamid 
• 6578-33-2 2-(4-chloro-phenyl)-2-phenyl-ethylamine 

Relevant articles and documents

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Scalable α-Arylation of Nitriles in Aqueous Micelles using Ultrasmall Pd Nanoparticles: Surprising Formation of Carbanions in Water

A scalable synthetic method is described for both the preparation of ultrasmall palladium nanoparticles and their subsequent use in catalyzing an α-arylation reaction of nitriles in aqueous micelles. This method involves the intermediacy of carbanions or keteniminates, which are presumably stabilized by the micellar environment rather than being quenched with water. These Pd nanoparticles are thoroughly characterized. Mechanistic studies using 31P NMR spectroscopy revealed the binding of phosphine ligand with the Pd surface and control experiment confirmed the zero-oxidation state of palladium. The scope of the transformation is demonstrated over 35 examples, including one at 50 g scale.

Synthesis and structure-activity relationships of A novel class of dithiocarbamic acid esters as anticancer agent

Based on a novel lead compound 4-methylpiperazine-1-carbodithioic acid 3-cyano-3,3-diphenylpropyl ester 1, the systematic structural modification was carried out. All the synthesized compounds were evaluated for their in-vitro anticancer activities on four to six different cell lines at three different concentrations. Most of the tested compounds could selectively inhibit the growth of HL-60 and Bel-7402 cell lines at a medium concentration. Four compounds (3f, 3g, 3n, and 5) were selected for the IC50 test, and the results revealed that three compounds (3g, 3n, and 5) showed almost the same or a slightly weaker activity than compound 1 against HL-60, and three compounds (3f, 3g, and 3n) showed >2-fold higher potency than compound 1 against Bel-7402. The in-vivo efficacy of 3n · HCl was evaluated with transplanted hepatocyte carcinoma 22 as an in-vivo test model. It was found that 3n · HCl could inhibit significantly the growth of tumor, and that this effect was dose-dependent. Meanwhile, the compound 3n · HCl showed low toxicity compared with compound 1 · HCl as evidenced by the little body-weight loss. These results confirmed that compound 3n · HCl is more potent than the lead compound 1 · HCl. Preliminary structure-activity relationships indicated that: a) Both nitrile group and the cyclic amine containing at least two nitrogens were indispensable moieties to keep the activity; b) substitution of the piperazine ring is unfavorable for the improvement of activity; c) the suitable linker joining the piperazinyl dithiocarboxyl and diphenylacetonitril group should be ethylene; d) a non-coplanar arrangement of the two benzene rings appears to be essential for activity. Based on a novel lead compound 4-methyl-piperazine-1-carbodithioic acid 3-cyano-3,3-diphenyl-propyl ester 1, the systematic structural modification was carried out. Compounds 3g and 3n were found to show more potent biological activities than lead compound 1. Some useful SARs were revealed Copyright