5374-06-1

Usage

Uses

Used in Pharmaceutical Industry:
4,6-Di(tert-butyl)benzene-1,3-diol is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Chemical Research:
In the field of chemical research, 4,6-di(tert-butyl)benzene-1,3-diol serves as a valuable compound for studying the properties and reactivity of phenols. Its aromatic rings and hydroxyl functional groups make it an interesting subject for exploring new reaction mechanisms and potential applications in material science.
Used in Material Science:
4,6-Di(tert-butyl)benzene-1,3-diol is used as a building block for the development of new materials with specific properties. Its stability and ability to participate in chemical reactions make it a promising candidate for creating advanced materials with applications in various industries, such as electronics, coatings, and adhesives.

InChI:InChI=1/C14H22O2/c1-13(2,3)9-7-10(14(4,5)6)12(16)8-11(9)15/h7-8,15-16H,1-6H3

Upstream product

• 507-19-7 t-butyl bromide 
• 108-46-3 recorcinol 
• 20784-81-0 2,4,6-Tri-tert.-butyl-cyclohexen-⁽⁵⁾-dion-(1,3) 
• 75-65-0 tert-butyl alcohol 
• 1634-04-4 tert-butyl methyl ether 
• 115-11-7 isobutene 
• 75376-45-3 sodium salt of 2,4-di-tertbutylphenol 

Downstream Products

• 61575-88-0 cis-4,6-di-tert-butylcyclohexane-1,3-dione 
• 55579-78-7 trans-4,6-di-tert-butylcyclohexane-1,3-dione 
• 15910-52-8 2,4-di-tert-butyl-5-methoxyphenol 
• 129056-51-5 1-(3-tert-butyl-4,6-dihydroxyphenyl)-3-methyl-2-buten-1-one 
• 129056-50-4 2',4'-di-tert-butyl-5'-hydroxyphenyl 3-methylbut-2-enoate 
• 116935-77-4 4,6-di-t-butyl-2-(4-nitrophenylazo)resorcinol 
• 116935-76-3 4,6-di-t-butyl-2-phenylazoresorcinol 
• 85630-04-2 5-[2,4-Di-tert-butyl-5-(4-methoxycarbonyl-4-methyl-pentyloxy)-phenoxy]-2,2-dimethyl-pentanoic acid methyl ester 
• 111841-31-7 2,4-bis(1,1-dimethylethyl)-5-(dodecyloxy)phenol 
• 129056-49-1 6-tert-butyl-7-hydroxy-2,2-dimethyl-4-chromanone 
• 5008-12-8 4-tert-Butoxy-6-tert-butyl-benzene-1,3-diol 
• 5063-76-3 1-Hydroperoxy-6-hydroxy-1.3-di-tert-butyl-cyclohexadien-(2.5)-on-⁽⁴⁾ 
• 4857-70-9 2-tert-butyl-5-hydroxy-1,4-benzoquinone 
• 38475-56-8 4,6-di-tert-butyl-3-hydroxy-[1,2]benzoquinone 

Relevant academic research and scientific papers

Reaction of sterically congested phenols and quinones with organic radicals

In the course of radiation-induced free-radical transformations of hexane and ethanol, pyrocatechol and hydroquinone derivatives, as well as their respective quinones, are more effective than phenol and resorcinol derivatives in controlling reactions that involve alkyl and hydroxyalkyl radicals. The opposite result takes place in the inhibition by phenols of hexane oxidation in which the key role belongs to the peroxyl radicals generated from the starting compounds. 2005 Pleiades Publishing, Inc.

Preparation method of large-steric-hindrance biphenyl tetra-phenol skeleton and phosphite ligand thereof

The invention discloses a large-steric-hindrance biphenyl tetra-phenol skeleton and a phosphite ligand thereof, which have good conversion rate and normal paraffin isomerization in hydroformylation reaction between 2,2',6,6'-tetra[(1,1,3-butadiene) and C5-C10 or above olefin.

Synthesis method of novel large-steric-hindrance biphenol skeleton and tridentate phosphite ligand thereof

The invention discloses a synthesis method of a novel large-steric-hindrance biphenol skeleton 2, 2', 6-trihydroxy-3, 3', 5, 5'-tetra-tert-butyl-1, 1'-biphenyl and a tridentate phosphite ligand thereof. The novel biphenyl tridentate phosphite ligand has a structure as shown in a general formula I, and a substituent R in the general formula I can be a cyclic phosphine structure. The novel biphenyltridentate phosphite ligand has good conversion rate and normal-to-isomeric ratio in a mixed/etherified C4(butylene) hydroformylation reaction system.

Alkylation of resorcinol with tertiary butanol over zeolite catalysts: Shape selectivity vs acidity

The catalytic performance of various zeolites such as H-ZSM-5, H-Y, H-beta, H-Mordenite in resorcinol alkylation with tertiary butanol demonstrated that pore characteristics have major influence on product selectivity, whereas acid strength and number of acid sites influenced resorcinol conversion. The passivation of external surface of H-beta zeolite by silylation and amine poisoning produced shape selectively O-alkylated resorcinol methyl tert butyl ether (RMTBE) and 4-tert butyl resorcinol (4-TBR). We propose that 4-TBR formation goes over external acid sites through RMTBE isomerization, whereas formation of 4-TBR takes place inside the pores through direct C-alkylation mechanism.

Biphenol compound as well as preparation method and application thereof

The invention discloses a biphenyl triphenol compound. The compound has a structure as shown in the following formula (I). The biphenyl triphenol compound provided by the invention is an important intermediate for synthesizing a tridentate phosphite ligand of a biphenyl frame, and plays an important role in hydroformylation reaction and industrial application thereof. The invention also provides preparation methods of various biphenol compounds, including an oxidative coupling method; the oxidative coupling method provided by the invention can be used for synthesizing the biphenol compounds inone step; and the method has the advantages of cheap and easily available catalyst, simple operation, good yield, low cost and large-scale preparation.

Biphenyltridentate phosphite ligand and preparation method and application thereof (by machine translation)

The invention discloses a biphenyl tridentate phosphite ligand and a preparation method and application thereof, wherein the biphenyltridentate phosphite ligand has the structure shown in a formula (I), and the ligand has extremely stable water oxygen. The catalyst is not easy to decompose and has good catalytic activity. (by machine translation)

Preparation of novel biphenyl tetradentate phosphite ligand and application of novel biphenyl tetradentate phosphite ligand in mixed/etherified C4 hydroformylation reaction

The invention discloses a preparation method of a novel biphenyl tetradentate phosphite ligand 2, 2 ', 6, 6'-tetra [(1, 1 'biphenyl-2, 2'-diyl) phosphite]-3, 3 ', 5, 5'- tetra-tert-butyl -1, 1- 'biphenyl and derivatives thereof. The novel biphenyl tetradentate phosphite ligand has a structure as shown in general formula I, wherein a substituent R in the general formula I can be a cyclic phosphinestructure. Meanwhile, the invention discloses an application in a mixed/etherified C4 (butene) hydroformylation reaction system taking a novel biphenyl tetradentate phosphite ligand as a ligand.

Cambiarenes: Single-Step Synthesis and Selective Zwitterion Binding of a Clip-Shaped Macrocycle with a Redox-Active Core

A novel macrocyclic host molecule was synthesized that forms in a single step from commercially available starting materials. The core of the macrocycle backbone possesses two quinone rings and, thus, it is redox-active. Host–guest binding involving the clip-shaped cavity indicates selective binding of pyridine N-oxides based on the electron density of and steric bulk around the anionic oxygen.

Role of Lewis and Br?nsted acid sites in resorcinol: Tert-butylation over heteropolyacid-based catalysts

The role of Br?nsted and Lewis acid sites at the surface of heteropolyacid-based catalysts was studied in resorcinol alkylation with methyl-Tert-butylether. Three sets of catalysts, SiO2/HPW, TiO2/HPW and ZrO2/HPW (where HPW stands for phosphotungstic acid hydrate), synthesized by the hydrolytic sol-gel method were investigated. The surface total acidity was characterized by ammonia chemisorption and thermo-programmed desorption. In addition, infrared analysis of adsorbed pyridine was performed to distinguish between Br?nsted and Lewis sites. The resorcinol conversion was correlated to the fraction of Br?nsted sites present at the catalyst surface based on the total acidity. The results pointed out the importance of considering both Br?nsted and Lewis sites as active players in the mechanism of resorcinol alkylation: Lewis sites have the role of adsorbing the substrate close to the tert-butyl cation, which is formed on Br?nsted sites. Resorcinol conversion can be increased to a maximum if the right Br?nsted/Lewis ratio is attained at the catalyst surface.

Sulfated zirconia: An efficient catalyst for the Friedel-Crafts monoalkylation of resorcinol with methyl tertiary butyl ether to 4-tertiary butylresorcinol

Friedel-Crafts alkylation of resorcinol with methyl tertiary butyl ether was carried out over sulfated zirconia (SZ) catalysts in the liquid phase. The SZ catalysts were synthesized by an impregnation method with different sulfur amounts and characterized by XRD, FT-IR, nitrogen sorption, XPS, SEM, pyridine-FTIR, and NH3-TPD. The effect of the sulfur loading on the total acidity and catalytic activity was investigated. The influence of the nature of the solvents on the alkylation reaction was inspected in terms of their acceptor and donor numbers. The sulfur loading, amount of solvent, temperature, catalyst amount, mole ratio and reusability of the catalyst were examined. The SZ catalyst synthesized by impregnating 1 N sulfuric acid was found to be highly selective for the monoalkylation to 4-tertiary butyl resorcinol (72%) with a resorcinol conversion of ～70%. The catalyst was recycled thrice with a negligible decrease in the yield for 4-tertiary butylresorcinol. The SZ exhibited the best performance at low temperature (60 °C) among the different types of solid acid catalysts studied so far.