537684-14-3Relevant academic research and scientific papers
One-pot synthesis of alkyl styryl sulfides free from transition metal/ligand catalyst and thiols
Heredia, Adrian A.,Penenory, Alicia B.
, p. 991 - 997 (2013/03/14)
A new protocol for the one-pot synthesis of styryl alkyl sulfides was developed. This methodology involves the in situ generation of thiolate anions by nucleophilic substitution between potassium thioacetate and alkyl halides followed by fragmentation. Further reactions of these thiolate anions with substituted (E,Z)-β-styryl halides gave the corresponding sulfides with retention of stereochemistry in good to excellent yields. This procedure does not require a metal catalyst, it proceeds under mild conditions and in short times, and it is free from malodorous and air-sensitive alkyl thiols. Copyright
(E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof
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, (2008/06/13)
Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a
Z-styryl sulfone anticancer agents
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, (2008/06/13)
(Z)-styryl benzylsulfones of formula I are useful as anticancer agents: wherein R1is selected from the group consisting of hydrogen, chloro and nitro; R2is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, ch
Z-styryl sulfone anticancer agents
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, (2008/06/13)
(Z)-styryl benzylsulfones of formula I are useful as anticancer agents: wherein R1is selected from the group consisting of hydrogen, chloro and nitro; R2is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, ch
