537690-74-7

Upstream product

• 538368-86-4 2′,3′-di-O-benzoyl-L-threonolactone 

Downstream Products

• 325683-77-0 1-O-acetyl-2,3-di-O-benzoyl-L-threofuranose 
• 325683-79-2 1-(2',3'-di-O-benzoyl-α-L-threofuranosyl)thymine 
• 425394-07-6 N²,N⁶-dibenzoyl-9-(2',3'-di-O-benzoyl-α-L-threofuranosyl)-2,6-diaminopurine 
• 325683-81-6 N⁴-benzoyl-1-(2',3'-di-O-benzoyl-α-L-threofuranosyl)cytosine 

Relevant academic research and scientific papers

Nonenzymatic oligomerization of RNA by TNA templates

(Diagram presented) Cytosine TNA promotes nonenzymatic, template-directed oligomerization of complementary activated rGMP, leading to selective and efficient formation of RNA products. This process models "genetic takeover" of a pre-RNA by RNA.

The α-L-Threofuranosyl-(3′ → 2′)-oligonucleotide system ('TNA'): Synthesis and pairing properties

Our studies of α-L-Threofuranosyl-(3′ → 2′)-oligonucleotides ('TNA') are part of a systematic experimental inquiry into the base-pairing properties of potentially natural nucleic acid alternatives taken from RNA's close structural neighborhood. TNA is an efficient Watson-Crick base-pairing system and has the capability of informational cross-pairing with both RNA and DNA. This property, together with the system's constitutional and (presumed) generational simplicity, warrants special scrutiny of TNA in the context of the search for chemical clues to RNA's origin.