537692-26-5Relevant academic research and scientific papers
Synthesis of 1,3-selenazoles and bis(selenazoles) from primary selenocarboxylic amides and selenourea
Geisler, Karlheinz,Pfeiffer, Wolf-Diethard,Kuenzler, Andreas,Below, Harald,Bulka, Ehrenfried,Langer, Peter
, p. 875 - 884 (2007/10/03)
The reaction of nitriles with P2Se5 in the presence of EtOH-H2O afforded primary selenocarboxylic amides. The cyclization of these compounds with α-halo ketones afforded a variety of functionalized 1,3-selenazoles. The use of P2Se5 also allowed the convenient synthesis of selenocarboxylic diamides which were transformed into bis(selenazol-2-yl)alkanes ('bis-selenazoles'). A practical method for the synthesis of selenourea was developed. This useful small building block was successfully applied to the synthesis of primary 2-amino-1,3- selenazoles.
