537696-00-7

Upstream product

• 118-48-9 isatoic anhydride 
• 90802-45-2 DL-3-amino-2,6-piperidinone hydrobromide 
• 1121-89-7 piperidine-2,6-dione 
• 610-14-0 2-nitrobenzyl chloride 
• 39133-20-5 N-(2,6-dioxopiperidin-3-yl)-2-nitrobenzamide 
• 24666-55-5 3-(benzyloxycarbonyl)-amino-2,6-dioxopiperidine 

Relevant academic research and scientific papers

COMPOUNDS MODULATING PROTEIN RECRUITMENT AND/OR DEGRADATION

The invention provides cereblon binders for the degradation of proteins by the ubiquitin proteasome pathway for therapeutic applications.

SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION

Disclosed are small molecules against cereblon to enhance effector T cell function. Methodos of making thes molecules and methods of using them to treat various disease states are also disclosed.

Studies towards the synthesis of the benzodiazepine alkaloid auranthine. Synthesis of an acetylated derivative

Different approaches towards the synthesis of auranthine have been investigated. A completed synthesis of 3-[2-(4-oxo-3,4-dihydro-quinazolin-2-yl)- ethyl]-3,4-dihydro-1H-benzo[e][1,4]-diazepine-2,5-dione, an auranthine precursor, which after dehydration w