5378-29-0

Basic information

• Product Name: 3-(1,3,4-OXADIAZOL-2-YL)PHENOL
• Synonyms: 3-(1,3,4-OXADIAZOL-2-YL)PHENOL;3-(1,3,4-oxadiazol-2-yl)phenol(SALTDATA: FREE)
• CAS NO: 5378-29-0
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.15
• Mol File: 5378-29-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 503.7°C at 760 mmHg
• Flash Point: 244.5°C
• Appearance: /
• Density: 1.243g/cm³
• Vapor Pressure: 2.83E-10mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: 3-(1,3,4-OXADIAZOL-2-YL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,3,4-OXADIAZOL-2-YL)PHENOL(5378-29-0)
• EPA Substance Registry System: 3-(1,3,4-OXADIAZOL-2-YL)PHENOL(5378-29-0)

Safety Data

• Hazardous Substances Data: 5378-29-0(Hazardous Substances Data)

Usage

General Description

3-(1,3,4-Oxadiazol-2-yl)phenol, also known as Oxadiazon, is a chemical compound used as an herbicide to control weeds and unwanted vegetation in various agricultural and horticultural settings. It works by inhibiting the growth of roots in germinating seeds, effectively preventing the establishment of weeds. Oxadiazon is typically applied as a pre-emergent herbicide, meaning it is used before the target weeds have emerged from the soil. It is considered to have low toxicity to humans and non-target organisms, but proper handling and application are still recommended to minimize any potential risks. Additionally, its use may be regulated in certain regions to prevent contamination of water sources and adverse effects on non-target plants and animals.

InChI:InChI=1/C17H17NO2/c1-10-2-8-13(9-3-10)18-16(19)14-11-4-5-12(7-6-11)15(14)17(18)20/h2-5,8-9,11-12,14-15H,6-7H2,1H3

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 5818-06-4 3-hydroxybenzoic hydrazide 
• 19438-10-9 methyl 3-hydroxybenzoate 
• 149-73-5 trimethyl orthoformate 
• 69026-14-8 3-benzyloxybenzoic acid 
• 61535-46-4 3-benzyloxy-benzoyl chloride 
• 228419-13-4 3-(benzyloxy)benzoic acid hydrazide 

Downstream Products

• 79463-12-0 2,3-epoxypropoxy-3-(1,3,4-oxadiazol-2-yl)benzene 
• 118778-80-6 1-<3-(1,3,4-oxadiazol-2-yl)phenoxy>-3-<4-(2-methoxyphenyl)-1-piperazinyl>-2-propanol 
• 79463-35-7 1-<3-(1,3,4-oxadiazol-2-yl)phenoxy>-3-(4-phenyl-1-piperazinyl)-2-propanol 

Relevant articles and documents

Substitution of terminal amide with 1H-1,2,3-triazole: Identification of unexpected class of potent antibacterial agents

3-Methoxybenzamide (3-MBA) derivatives have been identified as novel class of potent antibacterial agents targeting the bacterial cell division protein FtsZ. As one of isosteres for the amide group, 1,2,3-triazole can mimic the topological and electronic features of the amide, which has gained increasing attention in drug discovery. Based on these considerations, we prepared a series of 1H-1,2,3-triazole-containing 3-MBA analogues via isosteric replacement of the terminal amide with triazole, which had increased antibacterial activity. This study demonstrated the possibility of developing the 1H-1,2,3-triazole group as a terminal amide-mimetic element which was capable of both keeping and modulating amide-related bioactivity. Surprisingly, a different action mode of these new 1H-1,2,3-triazole-containing analogues was observed, which could open new opportunities for the development of antibacterial agents.

SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT

Substituted cyclopropyl compounds of formula (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

The synthesis of antihypertensive 3-(1,3,4-oxadiazol-2-yl) phenoxypropanolamines

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