5378-33-6

Basic information

• Product Name: 2-(3-chlorophenyl)-1,3,4-oxadiazole
• Synonyms: 2-(3-chlorophenyl)-1,3,4-oxadiazole
• CAS NO: 5378-33-6
• Molecular Formula: C₈H₅ClN₂O
• Molecular Weight: 180.5911
• Mol File: 5378-33-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3-chlorophenyl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-chlorophenyl)-1,3,4-oxadiazole(5378-33-6)
• EPA Substance Registry System: 2-(3-chlorophenyl)-1,3,4-oxadiazole(5378-33-6)

Safety Data

• Hazardous Substances Data: 5378-33-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-(3-chlorophenyl)-1,3,4-oxadiazole is used as a building block for the synthesis of various organic compounds with potential biological activities. Its presence in pharmaceutical research is due to its antibacterial and antifungal properties, making it a valuable component in the development of new drugs.
Used in Agrochemical Research:
In the agrochemical industry, 2-(3-chlorophenyl)-1,3,4-oxadiazole is utilized for its potential to exhibit biological activities that can be harnessed in the creation of pesticides or other agricultural chemicals to protect crops and enhance yields.
Safety Precautions:
2-(3-chlorophenyl)-1,3,4-oxadiazole should be handled with care and used in a well-ventilated area due to its potential health hazards. Proper safety measures, including the use of personal protective equipment, should be taken to minimize exposure and ensure the safety of those working with 2-(3-chlorophenyl)-1,3,4-oxadiazole.

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Relevant articles and documents

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Copper-Catalyzed Enantioconvergent Cross-Coupling of Racemic Alkyl Bromides with Azole C(sp2)?H Bonds

The development of enantioconvergent cross-coupling of racemic alkyl halides directly with heteroarene C(sp2)?H bonds has been impeded by the use of a base at elevated temperature that leads to racemization. We herein report a copper(I)/cinchona-alkaloid-derived N,N,P-ligand catalytic system that enables oxidative addition with racemic alkyl bromides under mild conditions. Thus, coupling with azole C(sp2)?H bonds has been achieved in high enantioselectivity, affording a number of potentially useful α-chiral alkylated azoles, such as 1,3,4-oxadiazoles, oxazoles, and benzo[d]oxazoles as well as 1,3,4-triazoles, for drug discovery. Mechanistic experiments indicated facile deprotonation of an azole C(sp2)?H bond and the involvement of alkyl radical species under the reaction conditions.

Method for constructing 2-(3-chlorophenyl)-1,3,4-oxadiazole in one step by using DMF as carbon source

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DMF as Methine Source: Copper-Catalyzed Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles

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Novel, fast and efficient one-pot sonochemical synthesis of 2-aryl-1,3,4-oxadiazoles

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