5378-34-7

Basic information

• Product Name: 2-(3-bromophenyl)-1,3,4-oxadiazole
• Synonyms: 2-(3-bromophenyl)-1,3,4-oxadiazole;1,3,4-OXADIAZOLE, 2-(3-BROMOPHENYL)-
• CAS NO: 5378-34-7
• Molecular Formula: C₈H₅BrN₂O
• Molecular Weight: 225.04
• Mol File: 5378-34-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(3-bromophenyl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-bromophenyl)-1,3,4-oxadiazole(5378-34-7)
• EPA Substance Registry System: 2-(3-bromophenyl)-1,3,4-oxadiazole(5378-34-7)

Safety Data

• Hazardous Substances Data: 5378-34-7(Hazardous Substances Data)

Usage

Uses

Used in Optoelectronic Devices:
2-(3-Bromophenyl)-1,3,4-oxadiazole is used as a fluorescent and phosphorescent material for its application in organic light-emitting devices. Its high thermal stability and efficient emission properties contribute to the performance and reliability of these devices.
Used in Organic Light-Emitting Diodes (OLEDs):
In the application industry of OLEDs, 2-(3-Bromophenyl)-1,3,4-oxadiazole is used as a key component to enhance the light-emitting efficiency and stability of the devices, thereby improving their overall performance.
Used in Organic Photovoltaics:
2-(3-Bromophenyl)-1,3,4-oxadiazole is utilized as a building block in the synthesis of materials for organic photovoltaics, where its properties can contribute to the efficiency and durability of solar cells.
Used in Biological Imaging and Sensing:
2-(3-Bromophenyl)-1,3,4-oxadiazole is studied for its potential use in the development of materials for biological imaging and sensing, capitalizing on its unique chemical structure and properties to advance these fields.

InChI:InChI=1S/C8H5BrN2O/c9-7-3-1-2-6(4-7)8-11-10-5-12-8/h1-5H

Upstream product

• 585-76-2 m-bromobenzoic acid 
• 73789-56-7 N-isocyaniminotriphenylphosphorane 
• 39115-96-3 3-bromo-benzoic acid hydrazide 
• 1895-39-2 sodium chlorodifluoroacetate 
• 624-84-0 formic acid hydrazide 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 1186333-17-4 ethyl 3-(3-(3-(1,3,4-oxadiazol-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1186334-84-8 2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,3,4-oxadiazole 

Relevant articles and documents

[4u202f+u202f1] Cyclization of benzohydrazide and ClCF2COONa towards 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5

A facile synthesis of 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5 via [4 + 1] cyclization of ClCF2COONa with non-amine compounds containing amino groups is developed. Of note, this is the first time that halofluorinated compounds are used as C1 synthon to construct deuterated nitrogen-heterocyclic compounds. The current protocol features simple operation, readily accessible raw materials, wide substrate scope and valuable products

2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use

In its many embodiments, the present invention provides certain iminothiazine dioxide compounds, including compounds Formula (I): and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein each of the variables shown in the formula are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including Alzheimer's disease, are also disclosed.

Efficient synthesis of 1,3,4-oxadiazoles promoted by NH4Cl

An efficient and inexpensive approach to the synthesis of 2-substituted and 2,5-disubstituted 1,3,4-oxadiazoles from arylhydrazides and orthoesters is reported using catalytic NH4Cl. The conditions are mild, and thus, compatible with a variety of functional groups. The optimized reaction is performed using 30 mol % of NH4Cl in 100% EtOH and is generally complete within 1 h for non-aromatic orthoesters and 2-10 h for aromatic orthoesters. The reaction permits both electron-releasing and electron-withdrawing groups on the arylhydrazide substrate. Most products are formed in high yields and require only minimal purification. Compared with earlier reports, the current reactions proceed in shorter time and require less of the orthoester.

2-SPIRO-SUBSTITUTED IMINOTHIAZINES AND THEIR MONO-AND DIOXIDES AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE

In its many embodiments, the present invention provides provides certain iminothiazine dioxide compounds, including compounds Formula (I): and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein each of the variables shown in the formula are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including Alzheimer's disease, are also disclosed

BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF

Compounds of formula A: Formula (1) pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases.

The reaction of (N-isocyanimino)triphenylphosphorane with benzoic acid derivatives: a novel synthesis of 2-aryl-1,3,4-oxadiazole derivatives

The reactions of benzoic acid derivatives with (N-isocyanimino)triphenylphosphorane proceed smoothly at room temperature to afford 2-aryl-1,3,4-oxadiazoles in high yields.