5378-62-1

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloro-5-(hydrazinocarbonyl)benzenesulfonamide is used as an intermediate in the synthesis of Besulpamide (B319750), an antihypertensive agent. It plays a vital role in the development of this medication, which is designed to help regulate blood pressure and maintain overall cardiovascular health.
Used in Antihypertensive Applications:
In the pharmaceutical industry, 2-Chloro-5-(hydrazinocarbonyl)benzenesulfonamide is used as a key component in the production of antihypertensive drugs. Its incorporation into the synthesis of Besulpamide contributes to the drug's ability to lower blood pressure, making it a valuable asset in the treatment of hypertension.
Used in Diuretic Applications:
2-Chloro-5-(hydrazinocarbonyl)benzenesulfonamide also exhibits diuretic activity in rats and dogs, which means it can potentially be used in the development of medications that increase urine production and help the body eliminate excess water and salts. This application can be particularly useful in the treatment of conditions like edema and certain types of kidney diseases.

InChI:InChI=1/C7H8ClN3O3S/c8-5-2-1-4(7(12)11-9)3-6(5)15(10,13)14/h1-3H,9H2,(H,11,12)(H2,10,13,14)

Upstream product

• 1211-77-4 3-sulfamoyl-4-chlorobenzoic acid ethyl ester 
• 1208-40-8 4-chloro-3-sulfamoylbenzoic acid methyl ester 
• 70049-77-3 3-(aminosulfonyl)-4-chlorobenzoyl chloride 
• 1215-67-4 4-Chlor-3-sulfamoyl-benzoesaeure-cyanmethylester 

Downstream Products

• 5378-46-1 N-(2-chloro-5-[1,3,4]oxadiazol-2-yl-benzenesulfonyl)-formimidic acid ethyl ester 
• 19915-59-4 2-Chloro-5-[1-phenyl-meth-(E)-ylidene-hydrazinocarbonyl]-benzenesulfonamide 
• 120242-42-4 2-Chloro-5-[1-(2-hydroxy-phenyl)-meth-(E)-ylidene-hydrazinocarbonyl]-benzenesulfonamide 
• 5565-89-9 2-chloro-5-(N'-formyl-hydrazinocarbonyl)-benzenesulfonamide 
• 120242-45-7 2-Chloro-5-[1-(3-nitro-phenyl)-meth-(E)-ylidene-hydrazinocarbonyl]-benzenesulfonamide 
• 103665-12-9 N-[N'-((1S)-1-carboxy-3-phenylpropyl)-L-alanyl]-4-[N²-(3-sulfamyl-4-chlorobenzoyl)hydrazino]-L-proline 
• 103580-37-6 N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-4-2-(3-sulfamyl-4-chlorobenzoyl)hydrazino>-L-proline ethyl ester 
• 126257-69-0 N--L-alanyl>-4-2-(3-sulfamyl-4-chlorobenzoyl)hydrazino>-L-proline ethyl ester 

Relevant academic research and scientific papers

Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides

A series of 53 nitro derivatives rationally designed were obtained by parallel synthesis and screened against Leishmania donovani. Six compounds exhibited IC50 values lower than standard drugs. Brief SAR analysis revealed that substitution is important to the activity. Nitrothiophene analogues were more potent than the nitrofuran ones. This was attributed to the ability of sulfur atoms in accommodating electrons from nitro group, which facilitate its reduction and therefore the formation of free radicals lethal to parasites.

Compounds for treating hypertension

Compounds of the formula STR1 and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.

COMPOUNDS FOR TREATING HYPERTENSION

Compounds of the formula STR1 and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.