53786-45-1

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate is used as an impurity in the production of Domperidone (Motilium) for its application as a dopamine blocker and antidopaminergic reagent. ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate plays a role in the development and formulation of Domperidone, which is utilized for its anti-emetic effects and as a peripheral dopamine receptor antagonist that does not cross the blood-brain barrier.
Used in Research and Development:
In the field of pharmaceutical research and development, ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate may be used to study the effects and interactions of Domperidone with dopamine receptors. This can contribute to the understanding of the compound's mechanism of action and its potential applications in treating various conditions related to dopamine receptor activity.

InChI:InChI=1/C14H20ClN3O2/c1-2-20-14(19)18-7-5-11(6-8-18)17-13-4-3-10(15)9-12(13)16/h3-4,9,11,17H,2,5-8,16H2,1H3

Upstream product

• 58859-46-4 ethyl 4-aminopiperidine-1-carboxylate 
• 89-61-2 2,5-dichloronitrobenzene 
• 53786-44-0 4-(4-chloro-2-nitro-anilino)-piperidine-1-carboxylic acid ethyl ester 

Downstream Products

• 85076-06-8 axamozide 
• 53786-46-2 4-(5-chloro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidine-1-carboxylic acid ethyl ester 
• 53786-28-0 5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one 

Relevant academic research and scientific papers

Method for synthesizing ethyl 4-[(2-amino-4-chloro)phenyl]-amino-N-piperidinecarboxylate

The invention provides a method for synthesizing ethyl 4-[(2-amino-4-chloro)phenyl]-amino-N-piperidinecarboxylate. A reaction route of the method is as described in the specification. The invention has the following beneficial effects: 1, the novel synthetic method is designed in the invention for preparation of a domperidone intermediate with a structure as shown in a formula (DP-2) and is implemented, and the method uses easily available raw materials and is high in safety coefficient, simple in reaction and beneficial for realizing of large-scale industrial production; and 2, no special production equipment is need in the method, industrial scale-up production can be easily carried out, and production cost for the domperidone intermediate is greatly lowered, so production cost for domperidone is substantially reduced.

Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: Optimization of the 4-substituted piperidine

In our continuing effort to identify CGRP receptor antagonists for the acute treatment of migraine, we have undertaken a study to evaluate alternative 4-substituted piperidines to the lead dihydroquinazolinone 1. In this regard, we have identified the piperidinyl-azabenzimidazolone and phenylimidazolinone structures which, when incorporated into the benzodiazepine core, afford potent CGRP receptor antagonists (e.g., 18 and 29). These studies produced a potent analog (18) which overcomes the instability issues associated with the lead structure 1. A general pharmacophore for the 4-substituted piperidine component of these CGRP receptor antagonists is also presented.

Neuroleptic n-oxacyclyl-alkylpiperidine derivatives

Neuroleptically active compounds of the formula STR1 wherein R6 and R10 are --H or CH3 ; R7 and R8 are independently --H, --F, --Cl, or --CH3 ; and R9 is --F, --Cl, --CH3, or --OCH3.