5379-86-2

Upstream product

• 120-72-9 indole 
• 5472-71-9 1-(4-morpholinomethyl)-1H-benzotriazole 
• 7309-48-0 4-methoxymethyl-morpholine 

Relevant academic research and scientific papers

Hf(OTf)4-Catalyzed regioselective N -aminomethylation of indoles and related NH-containing heterocycles

Figure presented Under Lewis acidic conditions using Hf(OTf)4, the aminomethylation of an indole derivative with a typical N,O-acetal preferentially produced kinetically favored N-aminomethylated indole derivatives instead of thermodynamically favored 3-aminomethylated indoles.

A general synthesis of 1-(dialkylaminomethyl)indoles

1-(N,N-Dialkylamino)methylindoles are prepared from the corresponding 1-(dialkylaminomethyl)benzotriazoles by treatment with indole and base. The aminoalkylation proceeds in high yield with good regioselectivity.