5472-71-9Relevant articles and documents
Synthesis and evaluation of hepatoprotective activity of some new mannich bases bearing benztriazole moiety
Rajasekaran, Aiyalu,Periyasamy, Muthusamy
experimental part, p. 366 - 370 (2011/10/30)
A series of benztriazoles bearing Mannich bases (2 -10) were synthesized from benztriazole by aminomethylation with formaldehyde and various substituted secondary amines. Titled compounds were synthesized by Mannich reaction and they were characterized by IR and 'HNMR spectroscopy. All these Mannich bases were screened for hepatoprotective activity on carbon tetrachloride induced liver damage in rats. Only compounds 4 (250 mg/kg) protected significantly the animals from carbon tetrachloride induced hepatotoxicity. Compound 4 N-morpholinyl methyl benztriazole exhibited significant activity comparable to that of standard drug silymarin.
Synthesis of novel α-amino-N-substituted thioacetimidates
Katritzky,Button,Busont
, p. 2865 - 2868 (2007/10/03)
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THE CHEMISTRY OF N-SUBSTITUTED BENZOTRIAZOLES. PART 18. A STUDY OF THE INFLUENCE OF STRUCTURE ON THE 1- TO 2-(N,N-DIALKYLAMINOALKYL)BENZOTRIAZOLE EQUILIBRIUM
Katritzky, Alan R.,Yannakopoulou, Konstantina
, p. 1121 - 1134 (2007/10/02)
The equilibrium constants, the associated free energies for the equilibria, and the free energies of activation for the isomerization process of a series of 1- and 2-(N,N-dialkylaminoalkyl)benzotriazoles of types (8)-(11) were calculated from the variable temperature 1H-nmr spectra.Trends in the magnitudes of these energies and equilibrium constants are correlated with the molecular structure.