53798-97-3Relevant academic research and scientific papers
RASAGILINE CITRAMIDE
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Paragraph 0133; 0136; 0137, (2013/04/13)
The subject invention provides rasagiline citramide and a composition containing N-propargyl-1(R)-aminoindan or a pharmaceutically acceptable salt thereof, and a compound of rasagiline citramide or a salt thereof.
Synthesis of citrate-ciprofloxacin conjugates
Md-Saleh, Siti R,Chilvers, Emily C.,Kerr, Kevin G.,Milner, Stephen J.,Snelling, Anna M.,Weber, Jan P.,Thomas, Gavin H.,Duhme-Klair, Anne-Kathrin,Routledge, Anne
scheme or table, p. 1496 - 1498 (2009/11/30)
Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12.
The design and synthesis of nucleoside triphosphate isosteres as potential inhibitors of HIV reverse transcriptase
Weaver, Richard,Gilbert, Ian H.
, p. 5537 - 5562 (2007/10/03)
We describe the synthesis of a variety of lipophilic isosteres of nucleoside triphosphates as potential anti-HIV agents. The citrate molecule proved to be a good mimic of triphosphate by modelling in terms of charge and spatial distribution. Several lipophile derivatives of citrate were conjugated to the precedented anti-HIV nucleoside d4T via ester and amide linkages. A novel synthesis of 5'-amino-d4T is included. Intramolecular rearrangement of several amide-linked isosteres are also reported, along with an alternative synthetic strategy to the desired amide-linked isosteres.
A FACILE PREPARATION OF ASYM-MONOMETHYL, SYM-MONOMETHYL AND ASYM-DIMETHYL CITRATE
Hirota, Kazuhiro,Kitagawa, Harukazu,Shimamura, Michiya,Ohmori, Shinji
, p. 191 - 194 (2007/10/02)
Asym-monomethyl citrate was prepared by hydrolysis of sym-dimethyl citrate.Sym-monomethyl and sym-dimethyl citrate were prepared by a selective hydrolysis of trimethyl citrate.
