53798-97-3

Basic information

• Product Name: 3-hydroxy-5-methoxy-3-(methoxycarbonyl)-5-oxopentanoic acid
• Synonyms: dimethyl citrate
• CAS NO: 53798-97-3
• Molecular Formula: C₈H₁₂O₇
• Molecular Weight: 220.1767
• Mol File: 53798-97-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 405.1°C at 760 mmHg
• Flash Point: 162.6°C
• Density: 1.378g/cm³
• Vapor Pressure: 2.99E-08mmHg at 25°C
• Refractive Index: 1.484
• CAS DataBase Reference: 3-hydroxy-5-methoxy-3-(methoxycarbonyl)-5-oxopentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-5-methoxy-3-(methoxycarbonyl)-5-oxopentanoic acid(53798-97-3)
• EPA Substance Registry System: 3-hydroxy-5-methoxy-3-(methoxycarbonyl)-5-oxopentanoic acid(53798-97-3)

Safety Data

• Hazardous Substances Data: 53798-97-3(Hazardous Substances Data)

Upstream product

• 1587-20-8 trimethyl citrate 
• 77-92-9 citric acid 
• 144-16-1 5-oxo-1,3-dioxolan-4-ylidenedi(acetic acid) 
• 67-56-1 methanol 
• 184834-31-9 [-(2-methoxy-2-oxoethyl)-5-oxo-1,3-dioxolan-4-yl]acetic acid 
• 4767-12-8 4,4-(5-oxo-1,3-dioxolane)diacetic acid anhydride 

Relevant articles and documents

RASAGILINE CITRAMIDE

The subject invention provides rasagiline citramide and a composition containing N-propargyl-1(R)-aminoindan or a pharmaceutically acceptable salt thereof, and a compound of rasagiline citramide or a salt thereof.

The design and synthesis of nucleoside triphosphate isosteres as potential inhibitors of HIV reverse transcriptase

We describe the synthesis of a variety of lipophilic isosteres of nucleoside triphosphates as potential anti-HIV agents. The citrate molecule proved to be a good mimic of triphosphate by modelling in terms of charge and spatial distribution. Several lipophile derivatives of citrate were conjugated to the precedented anti-HIV nucleoside d4T via ester and amide linkages. A novel synthesis of 5'-amino-d4T is included. Intramolecular rearrangement of several amide-linked isosteres are also reported, along with an alternative synthetic strategy to the desired amide-linked isosteres.

A FACILE PREPARATION OF ASYM-MONOMETHYL, SYM-MONOMETHYL AND ASYM-DIMETHYL CITRATE

Asym-monomethyl citrate was prepared by hydrolysis of sym-dimethyl citrate.Sym-monomethyl and sym-dimethyl citrate were prepared by a selective hydrolysis of trimethyl citrate.