5381-99-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is used as a reagent for the phosphorylation and phosphitylation of alcohols, which is crucial in the synthesis of nucleotides and nucleoside triphosphates. These compounds play a vital role in the development of pharmaceuticals, particularly in the creation of new drugs and therapies.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is utilized for the formation of H-phosphonates. These compounds are essential building blocks in the synthesis of various organic and inorganic molecules, contributing to the advancement of materials science and the development of new chemical products.
Used in Research and Development:
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is also employed in research and development settings, where its unique properties and reactivity are harnessed to explore new chemical reactions and mechanisms. This contributes to the expansion of scientific knowledge and the discovery of innovative applications in various industries.

InChI:InChI=1/C7H4ClO3P/c8-12-10-6-4-2-1-3-5(6)7(9)11-12/h1-4H

Upstream product

• 127-09-3 sodium acetate 
• 69-72-7 salicylic acid 
• 7719-12-2 phosphorus trichloride 

Downstream Products

• 117779-58-5 2-((2R,3S,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-benzo[1,3,2]dioxaphosphinin-4-one 
• 91303-31-0 C₃₄H₃₇O₈P 
• 140383-33-1 2-pentafluorophenoxy-4-oxo-5,6-benzo-1,3,2-dioxaphosphorinane 
• 110945-45-4 C₅₀H₄₄NO₁₃P 
• 134662-30-9 1,3-di-O-benzylglycerol 2-(triethylammonium phosphonate) 
• 207448-94-0 acetic acid 4-acetoxy-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-5-(4-oxo-4H-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

Synthesis and Biological Activity of 3,4,-Tri-О-Acetyl-N-Acetylglucosamine and Tetraacetylglucopyranose Conjugated with Alkyl Phosphates

Abstract: Conjugates of 3,4,6-tri-О-acetyl-N-acetylglucosamine and tetraacetyl glucopyranose with alkyl phosphates were synthesized. The dependence of their antibacterial and antituberculosis activities on the length of the alkyl substituent at the phosphate group was found. The conjugates with a decyl substituent exhibited in vitro the highest antituberculosis activity against Mycobacterium tuberculosis H37Rv (MIC 3?μg/mL) but the weakest effect towards Streptococcus aureus and Bacillus cereus (≤MIC 125 μg/mL). Vice versa, the conjugates with a cetyl substituent demonstrated the highest antibacterial activity in vitro towards S. aureus and B. cereus (MIC 16 μg/mL) but showed the lowest antituberculosis activity (MIC 12 μg/mL) among the compounds under study.

Synthesis and Antitubercular and Antibacterial Activities of Triethylammonium 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-D-glucopyranosyl Decyl Phosphate

Phosphorylation of 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-D-glucose at the anomeric hydroxy group gave previously unknown triethylammonium 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-D-glucopyranosyl phosphonate, and successive treatment of the latter with decan-1-ol and aqueous iodine afforded triethylammonium 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl phosphate.

Preparation of a protected phosphoramidon precursor via an H-Phosphonate coupling strategy

The preparation of a phosphoramidon precursor is described using a phosphorus(III) coupling protocol.

METHOD FOR PRODUCING ORGANOACYLPHOSPHITES

The invention relates to a method for producing organoacylphosphites, organophosphonites and organophosphinites by the condensation of phosphorus trihalogenides or organophosphorus halogenides with organic hydroxy group-carrying compounds in the presence