53813-56-2Relevant academic research and scientific papers
Further observations on the rhodium (I)-catalysed tandem hydrosilylation-intramolecular aldol reaction
Freiría, Marta,Whitehead, Andrew J.,Tocher, Derek A.,Motherwell, William B.
, p. 2673 - 2692 (2004)
The rhodium (I) catalysed tandem hydrosilylation-intramolecular aldol reaction provides a simple strategy for construction of a range of usefully functionalised five-membered rings from readily prepared 6-oxo-2-hexenoates in good yield and with good to excellent stereoselectivity. A series of silanes and rhodium catalysts have been investigated. Stereoselectivity proved to be highly dependant on the catalyst as well as on the substitution pattern of the parent substrate. The extension of this methodology for the synthesis of larger ring sizes has also been evaluated.
Type-II Intramolecular Cycloaddition of Alkenes with Vinylketenes Prepared by the Regiospecific Deprotonation of β,β-Disubstituted α,β-Unsaturated Acid Chlorides
Snider, Barry B.,Ron, Eyal,Burbaum, Beverly W.
, p. 5413 - 5419 (2007/10/02)
Treatment of β,β-disubstituted α,β-unsaturated acid chlorides with Et3N in the presence of an alcohol leads to mixtures of vinylketenes, which were trapped as the β,γ-unsaturated ester.These studies establish that deprotonation occurs largely on the less
