5382-30-9

Basic information

• Product Name: 1-TERT-BUTYL-PIPERIDIN-4-OL
• Synonyms: 1-TERT-BUTYL-PIPERIDIN-4-OL;1-(1,1-DiMethylethyl)-4-piperidinol
• CAS NO: 5382-30-9
• Molecular Formula: C₉H₁₉NO
• Molecular Weight: 157.25326
• Mol File: 5382-30-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 237.407°C at 760 mmHg
• Flash Point: 59.903°C
• Appearance: /
• Density: 0.978g/cm³
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.489
• CAS DataBase Reference: 1-TERT-BUTYL-PIPERIDIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TERT-BUTYL-PIPERIDIN-4-OL(5382-30-9)
• EPA Substance Registry System: 1-TERT-BUTYL-PIPERIDIN-4-OL(5382-30-9)

Safety Data

• Hazardous Substances Data: 5382-30-9(Hazardous Substances Data)

Usage

General Description

1-TERT-BUTYL-PIPERIDIN-4-OL is a chemical compound that belongs to the class of piperidines. Its molecular structure consists of a piperidine ring with a tert-butyl group attached to the nitrogen atom at the fourth position. This chemical is commonly used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of specialty chemicals. It may also be used as an intermediate in organic synthesis and in the development of new materials. 1-TERT-BUTYL-PIPERIDIN-4-OL is known for its potential as a building block in the development of novel compounds with diverse biological activities.

InChI:InChI=1/C9H19NO/c1-9(2,3)10-6-4-8(11)5-7-10/h8,11H,4-7H2,1-3H3

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 1465-76-5 1-tert-butyl-piperidin-4-one 

Downstream Products

• 1610034-62-2 (S)-2-(1-(4-((1-(2-fluoro-5-methoxyphenyl)piperidin-4-yl)oxy)phenyl)pyrrolidin-2-yl)acetonitrile 
• 1610034-61-1 (S)-2-(1-(4-(piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile 
• 1610034-60-0 (S)-tert-butyl 4-(4-(2-(cyanomethyl)pyrrolidin-1-yl)phenoxy)piperidine-1-carboxylate 
• 118811-07-7 tert-butyl 4-(tosyloxy)piperidin-1-carboxylate 
• 444661-64-7 7-[(1-tert-Butylpiperidin-4-yl)oxy]-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-one 
• 914656-06-7 3-[1-(1,1-Dimethylethyl)piperidin-4-yloxy]-N',2-diphenylquinoline-4-carbohydrazide 
• 914654-60-7 3-[1-(1,1-dimethylethyl)piperidin-4-yloxy]-2-phenylquinoline-4-carboxylic acid 
• 914654-59-4 methyl 3-[1-(1,1-dimethylethyl)piperidin-4-yloxy]-2-phenylquinoline-4-carboxylate 
• 5570-81-0 1-tert-butyl-4-chloropiperidine 

Relevant articles and documents

5-Hydroxyindole-2-carboxylic acid amides: Novel histamine-3 receptor inverse agonists for the treatment of obesity

Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer. Several pieces of evidence across different species, including primates, underscore the implication of the histamine 3 receptor (H3R) in the regulation of food intake and body weight and the potential therapeutic effect of H3R inverse agonists. A pharmacophore model, based on public information and validated by previous investigations, was used to design several potential scaffolds. Out of these scaffolds, the 5-hydroxyindole-2-carboxylic acid amide appeared to be of great potential as a novel series of H3R inverse agonist. Extensive structure-activity relationships revealed the interconnectivity of microsomal clearance and hERG (human ether-a-go-go-related gene) affinity with lipophilicity, artificial membrane permeation, and basicity. This effort led to the identification of compounds reversing the (R)-R-methylhistamine-induced water intake increase in Wistar rats and, further, reducing food intake in diet-induced obese Sprague-Dawley rats. Of these, the biochemical, pharmacokinetic, and pharmacodynamic characteristics of (4,4-difluoropiperidin- 1-yl)[1-isopropyl-5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl]-methanone 36 are detailed.

(Halo-benzo carbonyl)heterocyclo fused phenyl p38 kinase inhibiting agents

Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof: are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.