5382-30-9

Usage

Uses

Used in Pharmaceutical Industry:
1-TERT-BUTYL-PIPERIDIN-4-OL is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with unique therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 1-TERT-BUTYL-PIPERIDIN-4-OL is employed as a precursor in the production of agrochemicals, aiding in the creation of compounds that can enhance crop protection and yield.
Used in Specialty Chemicals Production:
1-TERT-BUTYL-PIPERIDIN-4-OL serves as a vital component in the manufacturing of specialty chemicals, where its unique structure allows for the creation of high-performance materials with specific applications.
Used in Organic Synthesis:
As an intermediate in organic synthesis, 1-TERT-BUTYL-PIPERIDIN-4-OL is utilized for its potential to form a variety of complex organic compounds, expanding the scope of chemical research and development.
Used in Material Development:
In the realm of material development, 1-TERT-BUTYL-PIPERIDIN-4-OL is applied as a building block for the creation of new materials, leveraging its structural properties to achieve innovative material properties and functionalities.

InChI:InChI=1/C9H19NO/c1-9(2,3)10-6-4-8(11)5-7-10/h8,11H,4-7H2,1-3H3

Upstream product

• 1465-76-5 1-tert-butyl-piperidin-4-one 
• 1445-73-4 1-Methyl-4-piperidone 

Downstream Products

• 5570-81-0 1-tert-butyl-4-chloropiperidine 
• 914654-59-4 methyl 3-[1-(1,1-dimethylethyl)piperidin-4-yloxy]-2-phenylquinoline-4-carboxylate 
• 1610034-62-2 (S)-2-(1-(4-((1-(2-fluoro-5-methoxyphenyl)piperidin-4-yl)oxy)phenyl)pyrrolidin-2-yl)acetonitrile 
• 1610034-61-1 (S)-2-(1-(4-(piperidin-4-yloxy)phenyl)pyrrolidin-2-yl)acetonitrile 
• 1610034-60-0 (S)-tert-butyl 4-(4-(2-(cyanomethyl)pyrrolidin-1-yl)phenoxy)piperidine-1-carboxylate 
• 118811-07-7 tert-butyl 4-(tosyloxy)piperidin-1-carboxylate 
• 444661-64-7 7-[(1-tert-Butylpiperidin-4-yl)oxy]-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-one 
• 914656-06-7 3-[1-(1,1-Dimethylethyl)piperidin-4-yloxy]-N',2-diphenylquinoline-4-carbohydrazide 
• 914654-60-7 3-[1-(1,1-dimethylethyl)piperidin-4-yloxy]-2-phenylquinoline-4-carboxylic acid 

Relevant academic research and scientific papers

5-Hydroxyindole-2-carboxylic acid amides: Novel histamine-3 receptor inverse agonists for the treatment of obesity

Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer. Several pieces of evidence across different species, including primates, underscore the implication of the histamine 3 receptor (H3R) in the regulation of food intake and body weight and the potential therapeutic effect of H3R inverse agonists. A pharmacophore model, based on public information and validated by previous investigations, was used to design several potential scaffolds. Out of these scaffolds, the 5-hydroxyindole-2-carboxylic acid amide appeared to be of great potential as a novel series of H3R inverse agonist. Extensive structure-activity relationships revealed the interconnectivity of microsomal clearance and hERG (human ether-a-go-go-related gene) affinity with lipophilicity, artificial membrane permeation, and basicity. This effort led to the identification of compounds reversing the (R)-R-methylhistamine-induced water intake increase in Wistar rats and, further, reducing food intake in diet-induced obese Sprague-Dawley rats. Of these, the biochemical, pharmacokinetic, and pharmacodynamic characteristics of (4,4-difluoropiperidin- 1-yl)[1-isopropyl-5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl]-methanone 36 are detailed.

Synthesis of 1-tert-butyl-4-chloropiperidine: Generation of an N-tert-butyl group by the reaction of a dimethyliminium salt with methylmagnesium chloride

(Chemical Equation Presented) Two efficient routes to 1-tert-butyl-4- chloropiperidine are described. In the first route, the key thionyl chloride mediated chlorination reaction features the use of tetrabutyl-ammonium chloride as an additive that effectively suppresses the formation of an elimination-derived side product. In the second route, a novel alternative synthesis of 1-tert-butyl-4-chloropiperidine was developed in which the tertiary butyl group on the nitrogen is efficiently generated through the addition of methylmagnesium chloride to a dimethyliminium salt in 71% overall yield.

(Halo-benzo carbonyl)heterocyclo fused phenyl p38 kinase inhibiting agents

Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof: are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.