914654-60-7

Basic information

• Product Name: 4-Quinolinecarboxylic acid, 3-[[1-(1,1-dimethylethyl)-4-piperidinyl]oxy]-2-phenyl-
• CAS NO: 914654-60-7
• Molecular Formula: C25H28N2O3
• Molecular Weight: 404.509
• Mol File: 914654-60-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Quinolinecarboxylic acid, 3-[[1-(1,1-dimethylethyl)-4-piperidinyl]oxy]-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Quinolinecarboxylic acid, 3-[[1-(1,1-dimethylethyl)-4-piperidinyl]oxy]-2-phenyl-(914654-60-7)
• EPA Substance Registry System: 4-Quinolinecarboxylic acid, 3-[[1-(1,1-dimethylethyl)-4-piperidinyl]oxy]-2-phenyl-(914654-60-7)

Safety Data

• Hazardous Substances Data: 914654-60-7(Hazardous Substances Data)

Upstream product

• 63330-58-5 3-hydroxy-2-phenyl-quinoline-4-carboxylic acid methyl ester 
• 5382-30-9 1-(1,1-dimethylethyl)-4-piperidinol 

Downstream Products

• 914656-06-7 3-[1-(1,1-Dimethylethyl)piperidin-4-yloxy]-N',2-diphenylquinoline-4-carbohydrazide 

Relevant articles and documents

N′,2-Diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II

Introduction of selected amine containing side chains into the 3-position of N′,2-diphenylquinoline-4-carbohydrazide based NK3 antagonists abolishes unwanted hPXR activation. Introduction of a fluorine at the 8-position is necessary to minimize unwanted hIKr affinity and a piperazine N-tert-butyl group is necessary for metabolic stability. The lead compound (8m) occupies receptors within the CNS following oral dosing (Occ90 7 mg/kg po; plasma Occ90 0.4 μM) and has good selectivity and excellent PK properties.