5382-42-3Relevant articles and documents
Manganese oxide promoted liquid-phase aerobic oxidative amidation of methylarenes to monoamides using ammonia surrogates
Wang, Ye,Yamaguchi, Kazuya,Mizuno, Noritaka
supporting information; experimental part, p. 7250 - 7253 (2012/08/28)
In the presence of amorphous MnO2, various methylarenes (even with two or more methyl groups) could be selectively converted into the corresponding primary monoamides in moderate to high yields. The observed catalysis was truly heterogeneous, and the retrieved amorphous MnO2 catalyst could be reused without an appreciable loss of its catalytic performance. Copyright
Neighbouring Group Participation of the N-Acyl Function. I: A Selective Conversion of Nitriles into Carboxamides by Formic Acid
Friedrich, Klaus,Zamkanei, Mohebullah,Zimmer, Ralph
, p. 404 - 408 (2007/10/03)
Aliphatic α-(acylamino)nitriles react with formic acid at room temperature to give the corresponding α-(acyl-amino)carboxamides with concomitant formation of one mole of carbon monoxide. This new reaction, which was first observed with 2-acylamino-2-cyano-3,6-dihydro-2H-thiapyranes 1, can also be used to convert other N-(α-cyanoalkyl) amides such as N-cyanomethylbenzamides 3, 5 and the 3,4-dihydro Reissert compound 16 into the corresponding carboxamides. Another application is a synthesis of 2-formylaminoacetamides 11. A mechanism for the reaction is proposed.
