5382-42-3

Basic information

• Product Name: quinoline-2-carboxamide
• Synonyms: 2-Quinolinecarboxamide; Quinoline-2-carboxamide
• CAS NO: 5382-42-3
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.1833
• Mol File: 5382-42-3.mol

Chemical Properties

• Boiling Point: 421.3°C at 760 mmHg
• Flash Point: 208.6°C
• Density: 1.27g/cm³
• Vapor Pressure: 2.64E-07mmHg at 25°C
• Refractive Index: 1.678
• CAS DataBase Reference: quinoline-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: quinoline-2-carboxamide(5382-42-3)
• EPA Substance Registry System: quinoline-2-carboxamide(5382-42-3)

Safety Data

• Hazardous Substances Data: 5382-42-3(Hazardous Substances Data)

Upstream product

• 13721-17-0 1-benzoyl-1,2-dihydro-quinoline-2-carbonitrile 
• 91-63-4 2-methylquinoline 
• 91-22-5 quinoline 
• 77287-34-4 formamide 

Downstream Products

• 91842-88-5 1,2,3,4-tetrahydroquinoline-2-carboxamide 
• 1436-43-7 quinoline-2-carbonitrile 
• 128624-26-0 1-(2-phenylethenyl)-3,3a,4,5-tetrahydroimidazo<1,5-a>quinoline 
• 93-10-7 quinoline-2-carboxylic acid 
• 5760-20-3 2-aminomethylquinoline 

Relevant articles and documents

Manganese oxide promoted liquid-phase aerobic oxidative amidation of methylarenes to monoamides using ammonia surrogates

In the presence of amorphous MnO2, various methylarenes (even with two or more methyl groups) could be selectively converted into the corresponding primary monoamides in moderate to high yields. The observed catalysis was truly heterogeneous, and the retrieved amorphous MnO2 catalyst could be reused without an appreciable loss of its catalytic performance. Copyright

A novel, selective free-radical carbamoylation of heteroaromatic bases by Ce(IV) oxidation of formamide, catalysed by N-hydroxyphthalimide

The Ce(IV)-NHPI system was used to generate a carbamoyl radical by oxidation of formamide; this nucleophilic radical has been successfully used in the carbamoylation of heteroaromatic bases.

Neighbouring Group Participation of the N-Acyl Function. I: A Selective Conversion of Nitriles into Carboxamides by Formic Acid

Aliphatic α-(acylamino)nitriles react with formic acid at room temperature to give the corresponding α-(acyl-amino)carboxamides with concomitant formation of one mole of carbon monoxide. This new reaction, which was first observed with 2-acylamino-2-cyano-3,6-dihydro-2H-thiapyranes 1, can also be used to convert other N-(α-cyanoalkyl) amides such as N-cyanomethylbenzamides 3, 5 and the 3,4-dihydro Reissert compound 16 into the corresponding carboxamides. Another application is a synthesis of 2-formylaminoacetamides 11. A mechanism for the reaction is proposed.