53821-46-8Relevant articles and documents
Total synthesis of nothapodytine b and (-)-mappicine
Boger, Dale L.,Hong, Jiyong
, p. 1218 - 1222 (1998)
Concise total syntheses of naturally occurring nothapodytine B (1, mappicine ketone) and ( - )-mappicine (3) are detailed. The approach is based on the implememation of a room-temperature, inverse electron demand Diels-Alder reaction of the N-sulfonyl-1-aza-1.3-butadiene 11 for assemblage of a pyridone 1) ring precursor central to the structure. A Friedlander condensation is utilized for constructing the AB ring system of 1 and 3. An acid-catalyzed reaction sequence is used to accomplish a deprotection with subsequent ring-closure for introduction of the C ring in a single step.
PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS
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Page/Page column 80, (2011/09/30)
The present invention relates to a compound represented by formula [I]: wherein: R1 is hydrogen, halogen, lower alkyl or cyano; Ring A is an optionally substituted heterocyclic group; Ring B is an optionally substituted 3 to 6-membered monocyclic group; and Y is optionally substituted amino, optionally substituted cyclic amino, optionally substituted aliphatic 3 to 6-membered monocyclyloxy, optionally substituted lower alkyl or optionally substituted lower alkyl-O-, or a pharmaceutically acceptable salt thereof, and to their use as PDE10 inhibitor.
Total synthesis of the cytotoxic alkaloid luotonin A
Wang, Haishan,Ganesan
, p. 9097 - 9098 (2007/10/03)
The structure of luotonin A was unambiguously confirmed by total synthesis. Deprotonation of 3-oxo-1H-pyrrolo[3,4-b]quinoline gave an anion which was coupled with 2-sulfinylaminobenzoyl chloride (prepared by reaction of anthranilic acid with thionyl chlor
Tricyclic quinoxalinediones
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, (2008/06/13)
Tricyclic quinoxalinediones of the formula: STR1 wherein X is alkyl, halogen, cyano, trifluoromethyl, nitro, hydroxy, amino, etc.; R 1 is H, etc.; R 2 is H, alkyl, cycloalkyl, alkenyl, alkynyl, cycloalkylalkyl, arylalkyl, substituted arylalkyl, aryl, or substituted aryl; W is H, CO 2 R 3, CO 2 Y, CONR 3 R 4, CONR 3 Y, CON(OR 3)R 4, COR 3, CN, tetrazolyl, or substituted alkyl; R 3 and R 4 independently are H, alkyl, cycloalkyl, alkenyl, alkynyl, etc.; Y is mono-substituted alkyl or di-substituted alkyl; and n is an integer 0 or 1, or a pharmaceutically acceptable salt thereof, which are useful as a selective antagonist of glutamate receptor for the treatment or prevention of various diseases in animals including human being, for example, minimizing damage of central nervous system induced by ischaemic or hypoxylic conditions, treatment and/or prevention of neurodegenerative disorders, and further analgesics, antidepressants, anxiolitics, and anti-schizophrenics.
Practical total synthesis of (+)-Camptothecin: The full story
Ciufolini, Marco A.,Roschangar, Frank
, p. 11049 - 11060 (2007/10/03)
The evolution of our strategy for the synthesis of (+)-Camptothecin and related substances is presented in detail.
Facile palladium-mediated substitution of chlorine in 2-chloroquinolines
Ciufolini, Marco A.,Mitchell, James W.,Roschangar, Frank
, p. 8281 - 8284 (2007/10/03)
Unlike ordinary aryl chlorides, the title heterocycles participate readily in Castro-Stephens, Stille, Suzuki, and carbonylation reactions under the catalytic influence of Pd(0).
Totalsynthese von (+)-Camptothecin
Ciufolini, Marco A.,Roschangar, Frank
, p. 1789 - 1791 (2007/10/03)
Keywords: Alkaloide; Asymmetrische Synthesen; Camptothecin; Naturstoffe
