53828-74-3Relevant academic research and scientific papers
Synthesis of Chromone-Containing Allylmorpholines through a Morita–Baylis–Hillman-Type Reaction
Chernov, Nikita M.,Shutov, Roman V.,Barygin, Oleg I.,Dron, Mikhail Y.,Starova, Galina L.,Kuz'mich, Nikolay N.,Yakovlev, Igor P.
supporting information, p. 6304 - 6313 (2018/11/10)
The first example of an unusual addition of chromone-substituted acrylic acid to enamines is described. The process shows high versatility concerning both enamines and chromones. The reaction is catalyzed by tertiary amines and is highly likely of Morita–
Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists
Smalley, Terrence L.,Boggs, Sharon,Caravella, Justin A.,Chen, Lihong,Creech, Katrina L.,Deaton, David N.,Kaldor, Istvan,Parks, Derek J.
, p. 280 - 284 (2015/02/19)
The farnesoid X receptor (FXR) may play a crucial role in a number of metabolic diseases and, as such, could potentially serve as a target for the development of therapeutics as a treatment for those diseases. Previous work has described GW4064 as an FXR
Process for the manufacture of 2,5-disubstituted pyridines
-
, (2008/06/13)
The present invention concerns a process for the preparation of a 2,5 disubstituted pyridine of the formula (I) which comprises the steps of a) reacting a compound of the formula (II)R1-CH=CH-R2(II)with an acrylic compound of the formula (III) to form a c
Reactions of Isoprene with Secondary Amines
Kazantsev, O. A.,Shirshin, K. V.,Danov, S. M.,Afon'shin, G. N.
, p. 300 - 303 (2007/10/03)
Reactions of isoprene with secondary amines in the presence of alkali metals yield isomeric aminoolefins: 1-dialkylamino-3-methyl-2-butenes, 1-dialkylamino-2-methyl-2-butenes, and 1-dialkylamino-3-methyl-1-butenes.The influence of temperature, structure of the secondary amine, amount of catalyst, and molar ratio of the reactants on the yield of aminoolefins and selectivity of their formation has been examined.
Synthesis of α-Cyanoenamines by Cyanation of α-Bromoimmonium Bromides and Dehydrobromination of β-Bromo-α-(dialkylamino)nitriles
Kimpe, Norbert De,Verhe', Roland,Buyck, Laurent De,Schamp, Niceas
, p. 3846 - 3857 (2007/10/02)
The reaction of α-bromoimmonium bromides 4 with potassium cyanide in dimethylformamide gave rise to β-bromo-α-(dialkylamino)nitriles 5, which were dehydrobrominated in various base solvent systems to afford (E)- and (Z)-α-cyanoenamines 2.An adaption of a previously published preparation of α-cyanoenamines starting from aldehydes via enamines led to an improved, efficient and fast synthesis of the title compounds.
Process for producing solanone, norsolanadione and intermediates therefor
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, (2008/06/13)
Described is a process for preparing solanone and norsolanadione using chemical intermediates defined according to the generic structure: STR1 wherein X is one of the moieties: STR2 wherein R represents hydrogen or methyl; wherein Y represents one of the structures: STR3 wherein one of the dashed lines represents a carbon-carbon single bond and the other of the dashed lines represents a carbon-carbon double bond; with the provisos that: (i) when Y is the moiety having the structure: STR4 then X is the moiety having the structure: STR5 (ii) when X is the moiety having the structure: STR6 then Y is the moiety having the structure: In preparing solanone, the compound having the structure: STR7 or a mixture of compounds defined according to the structure: STR8 is reacted with methyl lithium and the resulting intermediate is hydrolyzed and the resulting compound is dehydrated. In producing the norsolanadione, the compound having the structure: STR9 or a mixture of compounds according to the structure: STR10 is reacted with ethylene glycol or propylene glycol thereby forming a ketal and the resulting ketal is reacted with methyl lithium and the resulting intermediate is then hydrolyzed in the presence of acid.
