538322-03-1Relevant articles and documents
Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists
Wu, Wen-Lian,Burnett, Duane A.,Spring, Richard,Qiang, Li,Sasikumar, Thavalakulamgara K.,Domalski, Martin S.,Greenlee, William J.,O'Neill, Kim,Hawes, Brian E.
, p. 3668 - 3673 (2007/10/03)
Isosteric replacement of the urea group of lead compound 1 led to novel substituted piperidine phenylamide analogues. SAR on the electron-induced effects of various linkers as well as substituents on the phenyl rings and the piperidine nitrogen has been investigated. Many single-digit nanomolar MCH R1 antagonists have been identified from this series.