538324-22-0

Basic information

• Product Name: 4-(3'-cyano-biphenyl-4-yl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 538324-22-0
• Molecular Weight: 378.471
• Mol File: 538324-22-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(3'-cyano-biphenyl-4-yl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3'-cyano-biphenyl-4-yl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester(538324-22-0)
• EPA Substance Registry System: 4-(3'-cyano-biphenyl-4-yl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester(538324-22-0)

Safety Data

• Hazardous Substances Data: 538324-22-0(Hazardous Substances Data)

Upstream product

• 57988-58-6 4-(4-bromophenyl)-4-hydroxy-piperidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 150255-96-2 (3‐cyanophenyl)boronic acid 
• 163209-96-9 tert-butyl 4-(4-bromophenyl)-4-hydroxypiperidine-1-carboxylate 

Downstream Products

• 538324-23-1 4-carboxymethoxy-4-(3'-cyano-biphenyl-4-yl)-piperidine-1-carboxylic acid tert-butyl ester 
• 904283-14-3 4-[(4-chloro-3-trifluoromethyl-phenylcarbamoyl)-methoxy]-4-(3'-cyano-biphenyl-4-yl)-piperidine-1-carboxylic acid tert-butyl ester 
• 538324-24-2 4-(3'-cyano-biphenyl-4-yl)-4-[(3,5-dichloro-phenylcarbamoyl)-methoxy]-piperidine-1-carboxylic acid tert-butyl ester 
• 904283-15-4 N-(4-chloro-3-trifluoromethyl-phenyl)-2-[4-(3'-cyano-biphenyl-4-yl)-piperidin-4-yloxy]-acetamide 
• 538322-37-1 2-[4-(3'-cyano-biphenyl-4-yl)-piperidin-4-yloxy]-N-(3,5-dichloro-phenyl)-acetamide 

Relevant articles and documents

Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists

Isosteric replacement of the urea group of lead compound 1 led to novel substituted piperidine phenylamide analogues. SAR on the electron-induced effects of various linkers as well as substituents on the phenyl rings and the piperidine nitrogen has been investigated. Many single-digit nanomolar MCH R1 antagonists have been identified from this series.