163209-96-9

Basic information

• Product Name: 1-BOC-4-(4-BROMO-PHENYL)-PIPERIDIN-4-OL
• Synonyms: 1-Boc-4-(4-bromophenyl)-4-hydroxypiperidine;1-Piperidinecarboxylic acid, 4-(4-broMophenyl)-4-hydroxy-, 1,1-diMethylethyl ester;tert-butyl 4-(4-bromophenyl)-4-hydroxypiperidine-1-carboxylate
• CAS NO: 163209-96-9
• Molecular Formula: C₁₆H₂₂BrNO₃
• Molecular Weight: 356.25
• Product Categories: pharmacetical
• Mol File: 163209-96-9.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 438.1 °C at 760 mmHg
• Flash Point: 218.7 °C
• Appearance: /
• Density: 1.367 g/cm³
• Vapor Pressure: 1.9E-08mmHg at 25°C
• Refractive Index: 1.566
• PKA: 13.79±0.20(Predicted)
• CAS DataBase Reference: 1-BOC-4-(4-BROMO-PHENYL)-PIPERIDIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-(4-BROMO-PHENYL)-PIPERIDIN-4-OL(163209-96-9)
• EPA Substance Registry System: 1-BOC-4-(4-BROMO-PHENYL)-PIPERIDIN-4-OL(163209-96-9)

Safety Data

• Hazardous Substances Data: 163209-96-9(Hazardous Substances Data)

Usage

General Description

1-BOC-4-(4-Bromo-phenyl)-piperidin-4-ol is a chemical compound with the molecular formula C16H23NO2Br. It is a piperidine derivative with a BOC (tert-butyloxycarbonyl) protective group attached to the nitrogen atom. The compound also contains a 4-(4-bromo-phenyl) group, which is a benzene ring with a bromine substituent at the para position. The 4-ol indicates the presence of a hydroxyl group at the 4 position of the piperidine ring. 1-BOC-4-(4-BROMO-PHENYL)-PIPERIDIN-4-OL is commonly used as a building block in organic synthesis and pharmaceutical research, with potential applications in medicinal chemistry for the development of new drugs and biologically active compounds.

InChI:InChI=1/C16H22BrNO3/c1-15(2,3)21-14(19)18-10-8-16(20,9-11-18)12-4-6-13(17)7-5-12/h4-7,20H,8-11H2,1-3H3

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 106-37-6 1.4-dibromobenzene 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 589-87-7 1,4-bromoiodobenzene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 57988-58-6 4-(4-bromophenyl)-4-hydroxy-piperidine 
• 92206-72-9 4-bromobenzylmagnesium bromide 

Downstream Products

• 538324-22-0 4-(3'-cyano-biphenyl-4-yl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 163209-97-0 Methyl 3-[4-(N-BOC-4-Hydroxypiperidin-4-yl)phenyl]acrylate 
• 1187313-08-1 tert-butyl 4-(4-bromophenyl)-4-methoxypiperidine-1-carboxylate 
• 1093064-85-7 tert-butyl 4-fluoro-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine-1-carboxylate 
• 57988-58-6 4-(4-bromophenyl)-4-hydroxy-piperidine 
• 1373265-31-6 tert-butyl 4-hydroxy-4-(4-morpholinophenyl)piperidine-1-carboxylate 
• 1399181-27-1 4-(1-(5-formyl-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile 
• 1399176-05-6 4-(1-(2,4-dimethyl-5-(6-(pyrrolidin-1-yl)-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl)piperidin-4-yl)benzonitrile 
• 1399181-40-8 4-(1-(3-formyl-4-methylbenzoyl)piperidin-4-yl)benzonitrile 
• 1399181-41-9 5-(4-(4-cyanophenyl)piperidine-1-carbonyl)-2-methylbenzoic acid 
• 1399176-26-1 5-(4-(4-cyanophenyl)piperidine-1-carbonyl)-2-methyl-N-(6-(pyrrolidin-1-yl)pyridin-3-yl)benzamide 
• 1399176-12-5 4-(1-(4-methyl-3-(6-(pyrrolidin-1-yl)-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl)piperidin-4-yl)benzonitrile 
• 1399176-16-9 4-(1-(2-methyl-5-(6-(pyrrolidin-1-yl)-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl)piperidin-4-yl)benzonitrile 
• 1415387-38-0 C₃₀H₃₀N₆O 

Relevant articles and documents

DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE

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RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

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METALLO-BETA-LACTAMASE INHIBITORS

The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.