538366-73-3

Upstream product

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• 943-14-6 2-bromo-5-nitrobenzoic acid 
• 59134-89-3 8-chloro-2H-[1,3]dioxolo[4,5-g]quinoline 

Relevant academic research and scientific papers

NITRO AND AMINO SUBSTITUTED TOPOISOMERASE AGENTS

The invention provides compounds of formula (I): wherein R1-R9, W, and X have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions compr

Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)2,3-methylenedioxy-5H-dibenzo[c,h][1,6] naphthyridin-6-ones: Effect on topoisomerase-I targeting activity and cytotoxicity

5H-8,9 -Dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxydibenzo [c,h][1,6]naphthyridin-6-one exhibits potent TOP1-targeting activity and pronounced antitumor activity. It was hypothesized that replacement of the two methoxyl groups with a nitro s