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Benzoyl chloride, 2-bromo-5-nitro- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 80887-01-0 Structure
  • Basic information

    1. Product Name: Benzoyl chloride, 2-bromo-5-nitro-
    2. Synonyms: 2-bromo-5-nitro-benzoyl chloride;2-Brom-5-nitro-benzoylchlorid;2-bromo-5-nitrobenzoylchloride;2-bromo-5-nitrobenzoic acid;2-bromo-5-nitrobenzoic acid chloride;3-nitro-6-bromo-benzoylchloride;
    3. CAS NO:80887-01-0
    4. Molecular Formula: C7H3BrClNO3
    5. Molecular Weight: 264.463
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 80887-01-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Benzoyl chloride, 2-bromo-5-nitro-(CAS DataBase Reference)
    10. NIST Chemistry Reference: Benzoyl chloride, 2-bromo-5-nitro-(80887-01-0)
    11. EPA Substance Registry System: Benzoyl chloride, 2-bromo-5-nitro-(80887-01-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 80887-01-0(Hazardous Substances Data)

80887-01-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 80887-01-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,8,8 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 80887-01:
(7*8)+(6*0)+(5*8)+(4*8)+(3*7)+(2*0)+(1*1)=150
150 % 10 = 0
So 80887-01-0 is a valid CAS Registry Number.

80887-01-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-bromo-5-nitrobenzoyl chloride

1.2 Other means of identification

Product number -
Other names 2-bromo-5-nitro-benzoyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:80887-01-0 SDS

80887-01-0Relevant articles and documents

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer

Hu, De-Xuan,Tang, Wen-Lin,Zhang, Yu,Yang, Hao,Wang, Wenjie,Agama, Keli,Pommier, Yves,An, Lin-Kun

, p. 7617 - 7629 (2021/06/25)

As a recently discovered DNA repair enzyme, tyrosyl-DNA phosphodiesterase 1 (TDP1) removes topoisomerase IB (TOP1)-mediated DNA protein cross-links. Inhibiting TDP1 can potentiate the cytotoxicity of TOP1 inhibitors and overcome cancer cell resistance to

Organocatalyst in Direct C(sp2)-H Arylation of Unactivated Arenes: [1-(2-Hydroxyethyl)-piperazine]-Catalyzed Inter-/Intra-molecular C-H Bond Activation

Yadav, Lalit,Tiwari, Mohit K.,Shyamlal, Bharti Rajesh Kumar,Chaudhary, Sandeep

, p. 8121 - 8141 (2020/07/16)

This article describes the identification of 1-(2-hydroxyethyl)-piperazine as a new, cost-effective, highly efficient organocatalyst, which promotes both inter- A nd intra-molecular direct C(sp2)-H arylations of unactivated arenes in the presence of potassium tert-butoxide. While the inter-molecular C-H arylation of unactivated benzenes with aryl halides (Ar-X; X = I, Br, Cl) toward biaryl syntheses underwent smoothly in the presence of only 10 mol percent organocatalyst, the intra-molecular C-H arylation catalytic system composed of 40 mol percent each of the catalyst and the additive (4-dimethylaminopyridine (DMAP)). The novel catalyst was also able to perform both inter- A nd intra-molecular direct arylations simultaneously in a single pot. The mechanistic studies confirmed the involvement of aryl radical anions and proceeded via a single-electron-transfer (SET) mechanism. The large substrate scope, high functional group tolerance, competition experiments, gram-scale synthesis, and kinetic studies further highlight the importance and versatile nature of the methodology as well as the compatibility of the new catalyst. To the best of our knowledge, this is the first report on any organocatalyst that reported detailed investigations of both inter- A nd intra-molecular direct C(sp2)-H arylations of unactivated arenes in a single representation.

Utilization of BozPhos as an Effective Ligand in Enantioselective C-H Functionalization of Cyclopropanes: Synthesis of Dihydroisoquinolones and Dihydroquinolones

Mayer, Camilla,Ladd, Carolyn L.,Charette, André B.

supporting information, p. 2639 - 2644 (2019/04/17)

The bisphosphine monoxide (R,R)-BozPhos enables enantioselective C-H functionalization of cyclopropanes in a palladium-catalyzed cyclization. The synthesis of a broad spectrum of dihydroisoquinolones and dihydroquinolones in good yields and high enantiomeric excess was achieved through the use of this hemilabile ligand. Furthermore, the isolation of an intermediary palladium(II)-BozPhos complex after oxidative addition was successful and a second complex provided further insight into bond length and angles through a crystal structure.

Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) Series

Elsayed, Mohamed S. A.,Nielsen, Jeffery J.,Park, Sungtae,Park, Jeongho,Liu, Qingyang,Kim, Chang H.,Pommier, Yves,Agama, Keli,Low, Philip S.,Cushman, Mark

, p. 10440 - 10462 (2018/12/11)

The present account describes the discovery and development of a new benzo[c]pyrrolo[2,3-h][1,6]naphthyridin-5-one (BPN) JAK inhibitory chemotype that has produced selective JAK inhibitors. Sequential palladium chemistry was optimized for the rapid access

Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor Complex

Zhang, Xiaojun,Glunz, Peter W.,Johnson, James A.,Jiang, Wen,Jacutin-Porte, Swanee,Ladziata, Vladimir,Zou, Yan,Phillips, Monique S.,Wurtz, Nicholas R.,Parkhurst, Brandon,Rendina, Alan R.,Harper, Timothy M.,Cheney, Daniel L.,Luettgen, Joseph M.,Wong, Pancras C.,Seiffert, Dietmar,Wexler, Ruth R.,Priestley, E. Scott

supporting information, p. 7125 - 7137 (2016/08/24)

Inhibitors of the tissue factor (TF)/factor VIIa complex (TF-FVIIa) are promising novel anticoagulants which show excellent efficacy and minimal bleeding in preclinical models. Starting with an aminoisoquinoline P1-based macrocyclic inhibitor, optimizatio

One-pot synthesis of 2-arylquinazolines and tetracyclic isoindolo[1,2-a]quinazolines via cyanation followed by rearrangement of ortho-substituted 2-halo-N-arylbenzamides

Gawande, Sachin D.,Zanwar, Manoj R.,Kavala, Veerababurao,Kuo, Chun-Wei,Rajawinslin,Yao, Ching-Fa

supporting information, p. 168 - 176 (2015/01/30)

The one-pot synthesis of substituted 2-arylquinazoline derivatives and tetracylic isoindolo[1,2-a]quinazoline via cyanation followed by rearrangement of ortho-substituted 2-halo-N-arylbenzamides is described. Using dimethyl sulfoxide (DMSO) as the solvent

A general synthesis of diversely substituted indazoles and hetero-aromatic derivatives from o-halo-(het)arylaldehydes or -phenones

Dubost, Emmanuelle,Stiebing, Silvia,Ferrary, Thibault,Cailly, Thomas,Fabis, Frédéric,Collot, Valérie

, p. 8413 - 8418 (2015/03/04)

A set of variously substituted indazoles and hetero-aromatic derivatives were synthesized from o-halo-(het)arylaldehydes using a palladium catalyzed amination followed by cyclization. Starting from phenones, this process was extended to give 3-substituted indazoles. Moreover, N-1-substituted-indazoles can be reached by this strategy using an optional selective N-1-alkylation step during the process. This methodology offers a general and easy route for the synthesis of regioselectively substituted indazoles.

Cis-Dichloroplatinum(II) complexes tethered to dibenzo[c,h][1,6] naphthyridin-6-ones: Synthesis and cytotoxicity in human cancer cell lines in vitro

Desbois, Nicolas,Pertuit, David,Moretto, Johnny,Cachia, Claire,Chauffert, Bruno,Bouyer, Florence

, p. 719 - 727 (2013/10/22)

A novel family of cisplatin-type complexes tethered to dibenzo[c,h][1,6] naphthyridin-6-one topoisomerase inhibitor via a polymethylene chain and their nonplatinated counterparts were prepared. Their potential cytotoxicity was assessed in three human colo

Chiral (Mercaptophenyl)oxazolines as auxiliaries for asymmetric coordination chemistry

Wenzel, Marianne,Meggers, Eric

experimental part, p. 3168 - 3175 (2012/09/07)

(4S)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)-4-nitrobenzenethiol {(S)-TS} and its tert-butyl derivative {(S)-TS'} were developed as chiral auxiliaries for the asymmetric synthesis of polypyridyl ruthenium complexes. In their deprotonated form, these (merca

Benzoylurea derivatives as a novel class of antimitotic agents: Synthesis, anticancer activity, and structure-activity relationships

Song, Dan-Qing,Wang, Yan,Wu, Lian-Zong,Yang, Peng,Wang, Yue-Ming,Gao, Li-Mei,Li, Yan,Qu, Jing-Rong,Wang, Yong-Hong,Li, Ying-Hong,Du, Na-Na,Han, Yan-Xing,Zhang, Zhi-Ping,Jiang, Jian-Dong

experimental part, p. 3094 - 3103 (2009/04/06)

Forty-six new compounds were synthesized on the basis of our knowledge of the 3-haloacylamino benzoylurea (HBU) series. Structure-activity relationship (SAR) analysis indicates that (i) the configuration of the chiral center in 1 (JIMB01) is not indispensable for the activity, (ii) the phenyl ring is essential, and (iii) a substitution at the 6-position of the phenyl ring with a halogen enhances the activity. Among the analogues, 11e and 14b bearing 6-fluoro substitution showed potent activities against nine human tumor cell lines, including CEM (leukemia), Daudi (lymphoma), MCF-7 (breast cancer), Bel-7402 (hepatoma), DU-145 (prostate cancer), PC-3 (prostate cancer), DND-1A(melanoma), LOVO (colon cancer), and MIA Paca (pancreatic cancer) with IC50 values between 0.01 and 0.30 μM. 14b inhibited human hepatocarcinoma by 86% in volume in nude mice. The mechanism of 14b is to inhibit microtubule assembly, followed by the M-phase arrest, bcl-2 inactivation, and then apoptosis. We consider 14b promising for further anticancer investigation.

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