53841-56-8

Basic information

• Product Name: pentafluoroprop-1-en-2-ol
• Synonyms: pentafluoroprop-1-en-2-ol
• CAS NO: 53841-56-8
• Molecular Weight: 148.032
• Mol File: 53841-56-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: pentafluoroprop-1-en-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: pentafluoroprop-1-en-2-ol(53841-56-8)
• EPA Substance Registry System: pentafluoroprop-1-en-2-ol(53841-56-8)

Safety Data

• Hazardous Substances Data: 53841-56-8(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 684-16-2 Hexafluoroacetone 

Downstream Products

• 64632-74-2 Cyclohexylperfluorisopropenylether 
• 53841-58-0 1,1-difluoro-2-acetoxy-3,3,3-trifluoropropene 
• 53841-60-4 2-benzoyloxy-1,1,3,3,3-pentafluoropropene 
• 57069-95-1 Iodopentafluoroacetone 
• 79-53-8 chloropentafluoroacetone 
• 60698-22-8 p-Nitrobenzol-azo-pentafluoroacetonhydrat 
• 60698-21-7 Benzol-azo-pentafluoroacetonhydrat 

Relevant articles and documents

One-pot synthesis of 3-fluoro-4-(trifluoromethyl)quinolines from pentafluoropropen-2-ol and their molecular modification

(Chemical Equation Presented) Pentafluoropropen-2-ol (PFP) was prepared by the reaction of hexafluoroacetone (HFA) with Mg/TMSCl. The one-pot tandem sequential reactions of PFP via Mannich addition with aldimines followed by Friedel-Crafts cyclization and aromatization afforded the title quinolines. A variety of corresponding 3-substituted quinolines were derived from the title quinoline by nucleophilic substitution of 3-fluorine with nucleophiles. A defluorinative transformation of the 4-trifluoromethyl group of the title quinoline with hydrazine afforded py razoloquinoline.