5385-65-9

Upstream product

• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 91-16-7 1,2-dimethoxybenzene 
• 4131-03-7 bis(3,4-dimethoxyphenyl)methanone 
• 7697-37-2 nitric acid 
• 123330-76-7 Acetic acid bis-(4,5-dimethoxy-2-nitro-phenyl)-methyl ester 
• 123330-77-8 C₁₈H₂₀N₂O₉ 

Downstream Products

• 116495-88-6 2,2'-diamino-3,3',4,4'-tetramethoxybenzophenone 
• 861781-70-6 2-amino-4,5,4',5'-tetramethoxy-2'-phenacylamino-benzophenone 
• 861307-23-5 2,2'-bis-acetylamino-4,5,4',5'-tetramethoxy-benzophenone 
• 210404-96-9 2,3,10,11-tetramethoxy-6,7-dimethyl-dibenzo[c,f][2,7]naphthyridine 
• 99069-17-7 4-Acetylamino-1,2-dimethoxy-5-nitrobenzene 

Relevant academic research and scientific papers

COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE

Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A? amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinophathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

Biologically Useful Chelators That Take Up Ca(2+) upon Illumination

Two approaches were explored toward the goal of synthesizing physiologically useful Ca(2+)-selective chelators whose Ca(2+) affinities increase markedly upon photolysis.In the first approach, the known Ca(2+)-selective chelator 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) was masked with a variety of photoremovable protecting groups on one of its four carboxyl groups, reducing its affinity for Ca(2+) to ca. 1E5 M-1.Upon irradiation around 356 nm, free chelator with an affinity constant ca. 1E7 M-1 was regenerated but with very low quantumefficiencies (-1.Photochemical rearrangement of the diazoacetyl group converted it into an electron-donating carboxymethyl group, causing the Ca(2+) affinity to increase 30-fold to 1.4E7 M-1.The photolysis of Ca(2+)-free diazo-2 had a quantum efficiency with 365-nm light (λmax 370 nm, ε ca. 22000 M-1cm-1) of ca. 0.03 and generated the high-affinity chelator with rate constants of 2300 s-1 after a flash.Ca(2+) was then bound with association and dissociation rate constants of 8.0E8 M-1s-1 and 58 s-1, respectively.Diazo-2 was incorporated into rat fibroblasts either by microinjection or by incubation as the membrane-permeable, enzymatically labile tetrakis(acetoxymethyl) ester and, when flash-photolyzed, caused a drop in intracellular free to or below resting values of ca. 1E-7 M.An even larger increase in affinity(1600-fold) was obtained by substituting both phenyl rings of BAPTA with diazoacetyl substituents.Therefore, these chelators can be used to generate controlled fast decrements in intracellular free to mimic or ablate a host of important cellular responses, especially in nerve and muscle.