4131-03-7Relevant academic research and scientific papers
New Dopa-AIE Compound Used as Fluorescence Sensor Material: Specificity and Quantification for Cu(II)
Liu, Siwei,Cheng, Jing,Xu, Jiarui
, p. 335 - 340 (2017)
As a paramagnetic metal ion, Cu(II) is challenging to be detected by conventional fluorescence sensor because of its unselective paramagnetic quenching effects on common fluorophores. By combining catechol with tetraphenylethene, a typical aggregation-ind
A kind of LSD1 inhibitors and use thereof
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Paragraph 0019; 0022; 0023, (2019/07/04)
The invention relates to novel LSD1 inhibitors and application of the LSD1 inhibitors in drugs, in particular to application of the LSD1 inhibitors in preparing LSD1-resistant inhibitor drugs, drugs for treating tumor, virus infectious diseases, hematolog
Rigidification of a macrocyclic tris-catecholate scaffold leads to electronic localisation of its mixed valent redox product
Greatorex, Sam,Vincent, Kevin B.,Baldansuren, Amgalanbaatar,McInnes, Eric J. L.,Patmore, Nathan J.,Sproules, Stephen,Halcrow, Malcolm A.
supporting information, p. 2281 - 2284 (2019/02/27)
The catecholate groups in [{Pt(L)}3(μ3-tctq)] (H6tctq = 2,3,6,7,10,11-hexahydroxy-4b,8b,12b,12d-tetramethyltribenzotriquinacene; L = a diphosphine chelate) undergo sequential oxidation to their semiquinonate forms by voltammetry, with ΔE1/2 = 160-170 mV. The monoradical [{Pt(dppb)}3(μ3-tctq)]+ is valence-localised, with no evidence for intervalence charge transfer in its near-IR spectrum. This contrasts with previously reported [{Pt(dppb)}3(μ3-ctc)]+ (H6ctc = cyclotricatechylene), based on the same macrocyclic tris-dioxolene scaffold, which exhibits partly delocalised (class II) mixed valency.
One-Pot, Three-Component Approach to Diarylmethylphosphonates: A Direct Entry to Polycyclic Aromatic Systems
Prasad, Sure Siva,Singh, DIleep Kumar,Kim, Ikyon
, p. 6323 - 6336 (2019/05/24)
A new type of three-component reaction was developed consisting of aldehydes, electron-rich (hetero)arenes, and trialkyl phosphite, which provided facile access to a wide range of diarylmethylphosphonates under mild reaction conditions. Simple one- or two-step synthetic manipulation of the resulting compounds enabled us to reach several polycyclic (hetero)aromatic systems efficiently.
Process for producing ethylene/α-olefin copolymer
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Page/Page column 53, (2018/05/26)
A process capable of producing an ethylene/α-olefin copolymer having a high molecular weight even under the conditions of a high polymerization temperature is provided. The process for producing an ethylene/α-olefin copolymer includes copolymerizing ethyl
Synthesis and carbonic anhydrase isoenzymes i and II inhibitory effects of novel benzylamine derivatives
?etinkaya, Yasin,G??er, Hülya,G?ksu, Süleyman,Gül?in, Ilhami
, p. 168 - 174 (2014/04/03)
Synthesis and carbonic anhydrase inhibitory properties of novel diarylmethylamines 22-25 and sulfonamide derivatives 26-28 were investigated. Acylation of methoxy-substituted benzenes with benzene carboxylic acids, reduction of ketones with NaBH4, conversion of alcohols to azides, Pd-C catalyzed hydrogenation of azides afforded title compounds 22-25. Compounds 22, 24 and 25 were converted to sulfonamide derivatives 26-28 with MeSO2Cl. The inhibitory effects of novel benzylamine derivatives 22-28 were tested on human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes hCA I and II. The results demonstrated that compound 28 was found to be the best inhibitor against both hCA I (Ki: 3.68 μM) and hCA II (Ki: 9.23 μM).
One-pot synthesis of diarylmethanones through palladium-catalyzed sequential coupling and aerobic oxidation of aryl bromides with acetophenone as a latent carbonyl donor
Wang, Xing,Liu, Fu-Di,Tu, Hai-Yang,Zhang, Ai-Dong
, p. 6554 - 6562 (2014/08/05)
A one-pot palladium-catalyzed synthesis of symmetrical and unsymmetrical diarylmethanones using acetophenone and aryl bromides as raw materials has been developed. In this reaction, acetophenone acts as a latent carbonyl donor and two pathways of palladium-catalyzed sequential coupling and aerobic oxidation are identified. The reaction is applicable to a spectrum of substrates and delivers the products in moderate to good yields. This method can be used for the synthesis of ketoprofen, a nonsteroidal anti-inflammatory drug, in a two-step procedure and 45% overall yield.
Collective synthesis of several 2,7′-cyclolignans and their correlation by chemical transformations
Peng, Yu,Luo, Zhen-Biao,Zhang, Jian-Jian,Luo, Long,Wang, Ya-Wen
, p. 7574 - 7586 (2013/11/06)
Collective synthesis of anti-malarial 2,7′-cyclolignans has been stereoselectively achieved employing (±)-cyclogalgravin (2) as a linchpin through a series of functional group conversions, including redox reactions. Interestingly, 2 can be correlated with
AIE (AIEE) and mechanofluorochromic performances of TPE-methoxylates: Effects of single molecular conformations
Qi, Qingkai,Liu, Yifei,Fang, Xiaofeng,Zhang, Yumo,Chen, Peng,Wang, Yi,Yang, Bing,Xu, Bin,Tian, Wenjing,Zhang, Sean Xiao-An
, p. 7996 - 8002 (2013/07/19)
Two methoxy-substituted tetraphenylethylene (TPE) derivatives, tetra(4-methoxyphenyl)ethylene (TMOE) and tetra(3,4-dimethoxyphenyl)ethylene (TDMOE), were synthesized by McMurry reaction in high yields. The nearly centrosymmetric and natural propeller shape of TMOE and TDMOE excluded intermolecular effects, such as H or J-aggregation and π-π stacking, on their AIE (AIEE) and mechanofluorochromic performance. The crystal structures of TMOE and TDMOE, and theoretical calculations proved that their emission colours are determined by single molecular conjugation. These molecules were used to investigate pure conformational effects on molecular emissions. The spectral properties of these molecules in five environments of crystal(s), THF solution, THF-water binary solution, solidified THF and amorphous states, were investigated. The crystalline to amorphous phase transition by grinding resulted in good mechanofluorochromic performances with high quantum yields and distinguishable emission change, which was further explored as anti-counterfeiting inks on banknotes.
Cu(OAc)2-mediated cross-coupling reaction of benzophenone N,N,N-trimethylhydrazonium salts and aryl boronic acids
Kitamura, Mitsuru,Tokuda, Yu,Tashiro, Norifumi,Okauchi, Tatsuo
, p. 1687 - 1690 (2013/03/13)
Cu(OAc)2-mediated coupling of benzophenone N,N,N- trimethylhydrazonium salts and aryl boronic acids proceeded to afford N-aryl imines.
