53859-25-9Relevant academic research and scientific papers
Organocatalyzed enantioselective fluorocyclizations
Lozano, Oscar,Blessley, George,Martinez Del Campo, Teresa,Thompson, Amber L.,Giuffredi, Guy T.,Bettati, Michela,Walker, Matthew,Borman, Richard,Gouverneur, Veronique
, p. 8105 - 8109 (2011/10/03)
Enantioenriched fluorinated heterocycles can be prepared through fluorocyclizations of prochiral indoles (see scheme; Ts=tosyl, Bn=benzyl, Boc=tert-butoxycarbonyl). More than twenty examples for this cascade fluorination-cyclization, which is catalyzed by cinchona alkaloids and employs N-fluorobenzenesulfonimide as the electrophilic fluorine source have been explored, and an unprecedented catalytic asymmetric difluorocyclization has also been identified.
INDOLECARBOXYLIC ACID DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY
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Page/Page column 65, (2008/06/13)
Indolecarboxylic acid derivatives having DP receptor antagonistic activity and pharmaceutical compositions containing the compounds as active ingredients; and further relevant therapeutic agents for allergic diseases. There are provided compounds, their pharmaceutically acceptable salts or solvates thereof, the compounds represented by the general formula: (I) wherein the ring A is an aromatic carbon ring, etc.; the ring B is a nonaromatic-nitrogen-containing heterocycle, etc.; the formula -X1=X2-X3=X4- is the formula -C(R1)=C(R2)-C(R3)=C(R4)-, etc.; X5 is C(R5) or N; each of R1, R2, R3, R4 and R5 independently is a hydrogen atom, a halogen atom, etc.; R6 is the formula -Z-R10 (in which Z is alkylene, etc.; and R10 is carboxyl, etc.), etc.; R7 is an optionally substituted alkyloxy, etc.; each of R8s independently is a halogen atom, etc.; each of R9s independently is an optionally substituted alkyl, etc.; Y is a single bond, etc.; n is 0, etc.; and q is 0, etc.
