53859-89-5Relevant academic research and scientific papers
Perfluoroalkylated Calix[4]pyrroles: Fluoride Ion Extraction from an Aqueous Medium
Maji, Sinchan,Mandal, Debaprasad
supporting information, p. 2369 - 2373 (2017/09/06)
Octaalkenyl calix[4]pyrrole ((CH2=CH(CH2)2)8C4P) is highly useful for the postfunctionalization of different calix[4]pyrroles with desired functionalities. Functionalization with perfluoroalkyl chains [CF3(CF2)n; Rfn] gave perfluoroalkyl calix[4]pyrroles (Rfn(CH2)4)8C4P; n=6, 8), having >60 % fluorine content, which created a hydrophobic environment inside the calix[4]pyrrole cavity and recognized fluoride and chloride ions in solution as well as in the solid state. The fluoride ion is extracted efficiently from aqueous CsF and TBAF solutions by using (Rf6(CH2)4)8C4P, as droplets. The fluorinated chain generated a hydrophobic environment which broke the hydration shell associated with the anion and separated out fluoride ions as droplets from aqueous medium. Furthermore, the fluoride ions competitively replaced chloride ions from the (Rf6(CH2)4)8C4P cavity.
INDOLE CARBOXAMIDES AS IKK2 INHIBITORS
-
Page/Page column 98, (2008/12/04)
The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Concise assembly of the polycyclic frameworks associated with the hapalindole and fischerindole alkaloids
Banwell, Martin G.,Ma, Xinghua,Taylor, Rebecca M.,Willis, Anthony C.
, p. 4959 - 4961 (2007/10/03)
Reaction of N-methylindole (4) with 6,6-dibromobicyclo[3.1.0]hexane (5) in the presence of silver tetrafluoroborate affords conjugate 7 in 67% yield. This product can be readily elaborated to compounds 12b and 13b which embody the polycyclic frameworks as
THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES
-
, (2008/06/13)
This invention is therapeutically useful 2-aminotetralins and pharmaceutically acceptable acid addition salts thereof of the formula STR1 R, R 1 to R 5 and p are as defined in the specification, these compounds are useful to treat central nervous system disorders, hypertension, diabetes, sexual impotency and to control appetite.
