53866-33-4

Usage

Uses

17beta-Estradiol-2,4-d2 (CAS# 53866-33-4) is a useful isotopically labeled research compound.

InChI:InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14?,15?,16?,17-,18?/m0/s1/i3D,10D

Upstream product

• 50-28-2 estradiol 
• 22879-34-1 4-acetoxymercurio-1,3,5(10)-estratriene-3,17β-diol 

Relevant academic research and scientific papers

Shifted Selectivity in Protonation Enables the Mild Deuteration of Arenes through Catalytic Amounts of Bronsted Acids in Deuterated Methanol

Taking advantage of the "differentiating effect"of the solvent methanol, deuterations of electron-rich aromatic systems can be carried out under mild acid catalysis and thus under far milder conditions than known so far. The exceptional functional group t

Synthesis of C-2 and C-4 deuterium-labeled estradiol-17β

Estradiol-17β labeled with deuterium in the positions 2 or 4 can be prepared from 2-chloromercurio-1,3,5(10)-estratriene-3,17β -diol 3-methyl ether 17-acetate or 4-chloromercurio-1,3,5(10)-estratriene-3,17β -diol, respectively, in refluxing CH3COO2H/2H2O. The same reaction performed on 4-acetoxymercurio1,3,5(10)-estratriene-3,17β -diol afforded 2,4-dideuterio-estradiol-17β in good yields.