53872-44-9

Upstream product

• 53704-09-9 dimethyl 2-aminomalonate 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 53872-20-1 2-(4-fluoro-phenyl)-5-methoxy-oxazole-4-carboxylic acid methyl ester 
• 53872-28-9 2-(4-fluoro-phenyl)-5-(N-methyl-anilino)-oxazole-4-carboxylic acid methyl ester 
• 51974-35-7 2-(4-fluoro-phenyl)-5-methoxy-oxazole-4-carboxylic acid N-methyl-anilide 
• 1245318-85-7 N-(4,6-dihydroxypyrimidin-5-yl)-4-fluorobenzamide 
• 1245316-36-2 N-(4,6-dihydroxy-2-methylpyrimidin-5-yl)-4-fluorobenzamide 
• 1245319-06-5 N-(3-chloro-4-fluorophenyl)-2-(4-fluorophenyl)-oxazolo[5,4-d]pyrimidin-7-amine 
• 1245318-90-4 7-chloro-2-(4-fluorophenyl)-oxazolo[5,4-d]pyrimidine 

Relevant academic research and scientific papers

Investigation of the palladium-catalysed cyclisation of α-amido malonates with propargylic compounds

The palladium-catalysed cyclisation of propargylic electrophiles with nucleophiles represents a useful synthetic approach for the rapid construction of heterocyclic building blocks. However, these cyclisation reaction processes often pose a number of challenges due to the need for the simultaneous control of chemo-, regio- and stereoselectivity. Herein, we disclose the discovery of α-amido malonates as novel bis-nucleophiles in the highly chemo- and regioselective, as well as moderately enantioselective, palladium-catalysed cyclisation with propargylic compounds to afford a broad range of functionalised dihydrooxazine heterocycles. The new dihydrooxazine products will expand the suite of heterocycles available to medicinal chemists, and prompt the investigation of unchartered bis-nucloeophiles in palladium-catalysed cyclisation reactions en route to novel classes of heterocycle.