53882-15-8

Upstream product

• 535-87-5 3.5-diaminobenzoic acid 
• 5980-23-4 3,5-dichlorobenzamide 
• 541-73-1 1,3-Dichlorobenzene 
• 33786-93-5 3,5-diaminobenzonitrile 
• 121-81-3 3,5-dinitrobenzamide 

Downstream Products

• 75633-68-0 3,5-bis-acetylamino-benzoic acid amide 
• 53882-14-7 N-[3-Carbamoyl-5-(oxalyl-amino)-phenyl]-oxalamic acid 
• 33786-93-5 3,5-diaminobenzonitrile 
• 53882-16-9 N-[3-Carbamoyl-5-(ethoxyoxalyl-amino)-phenyl]-oxalamic acid ethyl ester 

Relevant academic research and scientific papers

Substrate Profiling of the Cobalt Nitrile Hydratase from Rhodococcus rhodochrous ATCC BAA 870

The aromatic substrate profile of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870 was evaluated against a wide range of nitrile containing compounds (>60). To determine the substrate limits of this enzyme, compounds ranging in size from small (90 Da) to large (325 Da) were evaluated. Larger compounds included those with a biaryl axis, prepared by the Suzuki coupling reaction, Morita–Baylis–Hillman adducts, heteroatomlinked diarylpyridines prepared by Buchwald–Hartwig crosscoupling reactions and imidazo[1,2a]pyridines prepared by the Groebke–Blackburn–Bienaymé multicomponent reaction. The enzyme active site was moderately accommodating, accepting almost all of the small aromatic nitriles, the diarylpyridines and most of the biaryl compounds and Morita–Baylis–Hillman products but not the Groebke–Blackburn–Bienaymé products. Nitrile conversion was influenced by steric hindrance around the cyano group, the presence of electron donating groups (e.g., methoxy) on the aromatic ring, and the overall size of the compound.

Crosslinkable polyimides obtained from a reactive diamine and the effect of crosslinking on the thermal properties

This study presents novel thermally crosslinkable polyimides (PIs)obtained using a diamine (3,5-DABA)containing an amide (CONH2)group. This diamine was highly reactive with pyromellitic dianhydride (PMDA), and the equimolar polyaddition in N-methyl-2-pyrrolidone at room temperature led to a high molecular weight poly(amic acid)(PAA)without causing gelation or precipitation. The results suggest that the amide side group of 3,5-DABA does not participate in PAA polymerization at room temperature. A PI system derived from PMDA and 2,2′-bis(trifluoromethyl)benzidine (TFMB), which has an ultralow coefficient of thermal expansion in the X–Y direction, was modified by copolymerization with 3,5-DABA. The FT-IR spectra suggested that the amide side groups in the 3,5-DABA-modified PIs can react with adjacent imide C=O groups to form crosslinks on heating above 350 °C, even in the absence of sufficient molecular fluidity. This behavior is attributed to the presence of a very high concentration of imide C=O groups distributed in the vicinity of the amide reactive groups. A crosslinking mechanism is proposed in this paper. An effect of crosslinking on the volumetric coefficient of thermal expansion (β)was investigated by comparing the 3,5-DABA-modified PIs with their crosslinker-free counterparts, i.e., a PI derived from PMDA with TFMB and m-phenylenediamine (m-PDA). At a 3,5-DABA content of 20 mol%, the 3,5-DABA-modified copolymer film showed a lower β value than that of the corresponding m-PDA-containing copolymer. The difference in the β values of these copolymers increased with increasing comonomer (3,5-DABA or m-PDA)content. Thus, the use of 3,5-DABA is effective in reducing the β values through crosslinking. Dynamic mechanical analysis showed that crosslinking also contributed to enhancing the storage modulus and broadening the glass transition. 3,5-DABA was also applied to modify the properties of a thermoplastic poly(ester imide)(PEsI). The thermal crosslinking of the 3,5-DABA-modified PEsI caused a Tg enhancement of about 30 °C and an appreciable decrease in the thermoplasticity. Thus, the present approach is also effective in improving the low-Tg character of thermoplastic PIs.

Triazole urease inhibitor type feed additive and preparation method thereof

The invention discloses a triazole urease inhibitor type feed additive and a preparation method thereof and belongs to the technical field of synthesis of feed additives. According to the technical scheme, a structural formula of the triazole urease inhibitor type feed additive is shown in the description. The invention further discloses the preparation method of the triazole urease inhibitor typefeed additive. The triazole urease inhibitor type feed additive prepared by the preparation method can be used as non-protein nitrogen and has a certain inhibition effect on urease; the triazole urease inhibitor type feed additive has the effects of sterilizing and resisting ulcer and has a potential of being used as an excellent animal feed additive.

Tetrazole urease inhibitor type feed additive and preparation method thereof

The invention discloses a tetrazole urease inhibitor type feed additive and a preparation method thereof and belongs to the technical field of synthesis of feed additives. According to the technical scheme, a structural formula of the tetrazole urease inhibitor type feed additive is shown in the description. The invention further discloses the preparation method of the tetrazole urease inhibitor type feed additive. The tetrazole urease inhibitor type feed additive prepared by the preparation method can be used as non-protein nitrogen and has a certain inhibition effect on urease; the tetrazoleurease inhibitor type feed additive has the effects of sterilizing and resisting ulcer and has a potential of being used as an excellent animal feed additive.

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

Nonpeptide inhibitors of measles virus entry

Measles virus (MV) is one of the most infectious pathogens known. Despite the existence of a vaccine, over 500 000 deaths/year result from MV or associated complications. Anti-measles compounds could conceivably reverse these statistics. Previously, we described a homology model of the MV fusion protein trimer and a putative binding site near the head-neck region. The resulting model permitted the identification of two nonpeptidic entry inhibitors. Here, we present the design, synthesis, and bioevaluation of several series of fusion inhibitors and describe their structure-activity relationships (SAR). Five simply substituted anilides show low-μM blockade of the MV, one of which (AS-48) exhibits IC50 = 0.6-3.0 μM across a panel of wild-type MV strains found in the field. Molecular field topology analysis (MFTA), a 2D QSAR approach based on local molecular properties (atomic charges, hydrogen-bonding capacity and local lipophilicity), applied to the anilide series suggests structural modifications to improve potency.

Cyano phenylene dioxamic molecules

Compounds represented below SPC1 And pharmaceutical compositions thereof, the compositions including the non-substituted phenylene dioxamates are useful in the prophylactic treatment of sensitized mammals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature.