53885-46-4

Upstream product

• 30433-91-1 [2-(2-thyenyl)ethyl]amine 
• 446-48-0 o-fluorobenzyl bromide 
• 50-00-0 formaldehyd 
• 272-14-0 thieno[3,2-c]pyridine 
• 345-35-7 2-fluorobenzyl chloride 

Downstream Products

• 150322-43-3 prasugel 
• 150322-38-6 5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one 

Relevant academic research and scientific papers

Method for preparing prasugrel intermediate

The invention discloses a method for preparing a prasugrel intermediate 5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-1,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine. The method comprises a following reaction route. As a result of experiments, the method provided by the invention has the advantages of simple operation, mild reaction conditions, low requirement on equipment, inexpensive and easy-to-obtain raw materials, high yield, and low production cost. An adopted solvent can synchronously recovered. The method can be easily applied in large-scale productions. The method meets the requirements of prasugrel industrialized production, and has industrial application value.

Synthesis of thienopyridine and furopyridine derivatives of therapeutic interest

5-Benzyl-4,5,6,7-tetrahydrothieno [3,2-c] pyridines and analogous furopyridines were synthesized by NaBH4 reduction of the corresponding quaternary ammonium salts (method A). In the former series, the same derivatives were obtained by condensing benzyl halides with tetrahydrothienopyridine (method B).