53914-66-2

Basic information

• Product Name: benzhydryl 4-(trifluoromethyl)benzoate
• Synonyms: benzhydryl 4-(trifluoromethyl)benzoate
• CAS NO: 53914-66-2
• Molecular Weight: 356.344
• Mol File: 53914-66-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzhydryl 4-(trifluoromethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: benzhydryl 4-(trifluoromethyl)benzoate(53914-66-2)
• EPA Substance Registry System: benzhydryl 4-(trifluoromethyl)benzoate(53914-66-2)

Safety Data

• Hazardous Substances Data: 53914-66-2(Hazardous Substances Data)

Upstream product

• 91-01-0 1,1-Diphenylmethanol 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 

Relevant articles and documents

Visible light photoredox-catalyzed deoxygenation of alcohols

Carbon-oxygen single bonds are ubiquitous in natural products whereas efficient methods for their reductive defunctionalization are rare. In this work an environmentally benign protocol for the activation of carbon-oxygen single bonds of alcohols towards a reductive bond cleavage under visible light photocatalysis was developed. Alcohols were activated as 3,5-bis(trifluoromethyl)-substituted benzoates and irradiation with blue light in the presence of [Ir(ppy)2( dtb-bpy)](PF6 ) as visible light photocatalyst and Hünig's base as sacrificial electron donor in an acetonitrile/water mixture generally gave good to excellent yields of the desired defunctionalized compounds. Functional group tolerance is high but the protocol developed is limited to benzylic, α-carbonyl, and α-cyanoalcohols; with other alcohols a slow partial C-F bond reduction in the 3,5-bis(trifluoromethyl)benzoate moiety occurs.