53918-41-5

Usage

Tetrazole derivative

A class of organic compounds with a five-membered ring composed of four nitrogen atoms and one carbon atom.
1-phenyl-5-(prop-2-yn-1-ylsulfanyl)-1H-tetrazole belongs to the tetrazole derivative class, which is a group of organic compounds characterized by a specific five-membered ring structure.

Biological activities

Known for its biological activities in pharmaceutical research.
This chemical compound is recognized for its potential biological activities, making it a subject of interest in pharmaceutical research.

Potential drug candidate

Used as a potential drug candidate in pharmaceutical research.
Due to its biological activities, 1-phenyl-5-(prop-2-yn-1-ylsulfanyl)-1H-tetrazole is considered a potential candidate for drug development.

Antimicrobial properties

Exhibits potent antimicrobial properties.
The compound has demonstrated the ability to inhibit or kill microorganisms, making it a promising candidate for new antibiotic medications.

Antifungal properties

Exhibits potent antifungal properties.
Similarly, the compound has shown the ability to combat fungal infections, suggesting its potential use in the development of antifungal medications.

Corrosion inhibitor

Shown potential as a corrosion inhibitor in metal protection applications.
1-phenyl-5-(prop-2-yn-1-ylsulfanyl)-1H-tetrazole has the potential to be used as a corrosion inhibitor, protecting metals from degradation and wear.

Safety measures

Important to handle and use with proper safety measures in a controlled environment.
As with all chemicals, it is crucial to follow proper safety protocols and use the compound in a controlled setting to minimize potential hazards.

Upstream product

• 32276-00-9 S,S-bis(1-phenyl-1H-tetrazol-5-yl) dithiocarbonate 
• 107-19-7 propargyl alcohol 
• 86-93-1 1-Phenyl-1H-tetrazole-5-thiol 
• 106-96-7 propargyl bromide 
• 103-72-0 phenyl isothiocyanate 
• 70381-98-5 prop-2-yn-1-yl 2,2,2-trichloroacetimidate 

Relevant academic research and scientific papers

Synthesis of 5-{[(1-Aryl-1H-1,2,3-triazol-4-yl)methyl]sulfanyl}-1-phenyl-1H-tetrazoles

Abstract: A series of novel 5-(1,2,3-triazolylmethylsulfanyl)tetrazole derivatives were synthesized by the click reaction from 1-phenyl-5-(prop-2-yn-1-ylsulfanyl)-1H-tetrazole and the corresponding azide. The reaction optimization results showed that higher yields are obtained using CuSO4 and sodium ascorbate in DMF–water (2:1). The product structures were established on the basis of various spectral data, and their evaluation for antimicrobial activity showed moderate to good results compared to standard drugs.

Photochemical Doyle-Kirmse Reaction: A Route to Allenes

This Letter describes the metal-free, blue-light-induced [2,3]-sigmatropic rearrangement of sulfonium ylides generated from donor/acceptor diazoalkanes and propargyl sulfides. The reaction furnishes highly functionalized allenes from a broad range of starting materials in decent yield. Mechanistic experiments supported by the literature data suggest singlet carbenes as intermediates in this reaction.

Alkylation of thiols with trichloroacetimidates under neutral conditions

Trichloroacetimidates are displaced with thiols to form the corresponding sulfides without the need for an added acid or base by simply heating the reactants in refluxing THF. This operationally simple procedure provides the corresponding sulfides in excellent yields with only the formation of the neutral trichloroacetamide as the side product. The imidate may also be formed in situ, allowing for a direct method for the formation of sulfides from alcohols. This reaction provides a general method for the synthesis of a variety of sulfides from inexpensive and readily available alcohol starting materials.

Nonsymmetrical azocarbonamide carboxylates as effective Mitsunobu reagents

A family of nonsymmetrical Mitsunobu reagents possessing both dialkyl amide and ester substituents was developed. These new reagents were readily prepared in a single pot from inexpensive, commercially available materials by using a scalable and environmentally friendly procedure. They were shown to exhibit activity parallel to that of diethyl azodicarboxylate/diisopropyl azodicarboxylate in a wide variety of Mitsunobu reactions. Importantly, the acyl hydrazine reaction byproducts were readily separable from the crude mixture by standard aqueous workup. In addition, the discovery of effective nonsymmetrical Mitsunobu reagents offers new directions for the ongoing development of this important reaction.

A convenient preparation of di-p-chlorobenzyl azodicarboxylate (DCAD) for mitsunobu couplings

Gram-scale synthesis of pure, bench-stable solid di-p-chlorobenzyl azodicarboxylate (DCAD) is performed in two steps without resorting to chromatography. This novel reagent effects Mitsunobu couplings with yields comparable to DEAD or DIAD, while addressi

Simplification of the Mitsunobu reaction. Di-p-chlorobenzyl azodicarboxylate: A new azodicarboxylate

(Chemical Equation Presented) Di-p-chlorobenzyl azodicarboxylate (DCAD) is introduced as a novel, stable, solid alternative to DEAD and DIAD for a variety of Mitsunobu couplings. DCAD/Ph3P-mediated reactions in CH 2Cl2 gen

SINGLE-STEP PREPARATION OF ALLYLIC SULFIDES HAVING 1-PHENYLTETRAZOLE-5-THIO GROUP FROM ALLYLIC ALCOHOLS USING S,S'-BIS(1-PHENYL-1H-TETRAZOL-5-YL) DITHIOCARBONATE AND REACTIONS INVOLVING THE ALLYLIC SULFIDES

The reaction of allylic alcohols and S,S'-bis(1-phenyl-1H-tetrazol-5-yl) dithiocarbonate (1) gave allylic sulfides having 1-phenyltetrazole-5-thio group in a single step.Furthermore, these allylic sulfides could be applied to carbon-carbon bond and carbon-sulfur bond formations by using Grignard reagents or carbanions in the presence of catalytic amount of copper(I) bromide or palladium (0), respectively.