53921-72-5Relevant articles and documents
Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)
Torrisi, Caterina,Bisbocci, Monica,Ingenito, Raffaele,Ontoria, Jesus M.,Rowley, Michael,Schultz-Fademrecht, Carsten,Toniatti, Carlo,Jones, Philip
scheme or table, p. 448 - 452 (2010/04/05)
A novel hexahydrobenzonaphthyridinone PARP-1 pharmacophore is reported, subsequent SAR exploration around this scaffold led to selective PARP-1 inhibitors with low nanomolar enzyme potency, displaying good cellular activity and promising rat PK properties.
Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines
Grunewald,Sall,Monn
, p. 433 - 444 (2007/10/02)
Compounds of the benzylamine (BA) class are potent inhibitors of phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28). Restriction of the aminomethyl side chain through its incorporation into a cyclic framework as in 1,2,3,4-tetrahydroisoquinoline (
Syntheses of cisoid and transoid analogs of phenethylamine.
Smissman et al.
, p. 109,112 (2007/10/04)
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