53921-72-5Relevant academic research and scientific papers
Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)
Torrisi, Caterina,Bisbocci, Monica,Ingenito, Raffaele,Ontoria, Jesus M.,Rowley, Michael,Schultz-Fademrecht, Carsten,Toniatti, Carlo,Jones, Philip
scheme or table, p. 448 - 452 (2010/04/05)
A novel hexahydrobenzonaphthyridinone PARP-1 pharmacophore is reported, subsequent SAR exploration around this scaffold led to selective PARP-1 inhibitors with low nanomolar enzyme potency, displaying good cellular activity and promising rat PK properties.
5-HT7 Receptor antagonists
-
Page/Page column 21-22, (2008/06/13)
The invention relates to compounds of structure (I) having pharmacological activity towards the 5-HT7 receptor, and more particularly to some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such
Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines
Grunewald,Sall,Monn
, p. 433 - 444 (2007/10/02)
Compounds of the benzylamine (BA) class are potent inhibitors of phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28). Restriction of the aminomethyl side chain through its incorporation into a cyclic framework as in 1,2,3,4-tetrahydroisoquinoline (
Synthesis of the Marine Alkaloids Aaptamine and Demethyloxyaaptamine and of the Parent Structure Didemethoxyaaptamine
Pelletier, Jeffrey C.,Cava, Michael P.
, p. 616 - 622 (2007/10/02)
The first synthesis of the novel marine alkaloids aaptamine and demethyloxyaaptamine is described, as well as the first synthesis of the parent heterocycle 1H-benzonaphthyridine (didemethoxyaaptamine).
