53924-03-1 Usage
Description
N-cyclohexyl-1H-indole-3-methylamine, also known as cyclohexyltryptamine or CHT, is a tryptamine derivative with a structure similar to the neurotransmitter serotonin. It is known for its psychoactive effects, including hallucinogenic and psychedelic properties, and acts as a partial agonist at serotonin receptors in the brain, leading to alterations in perception, mood, and cognition.
Uses
Used in Research Applications:
N-cyclohexyl-1H-indole-3-methylamine is used as a research chemical for studying the effects of psychoactive substances on the brain and their interactions with serotonin receptors.
Used in Pharmaceutical Industry:
N-cyclohexyl-1H-indole-3-methylamine is used as a potential therapeutic agent for treating mental health disorders such as depression and anxiety, due to its ability to modulate serotonin receptors.
However, it is important to note that due to its psychoactive nature and abuse potential, N-cyclohexyl-1H-indole-3-methylamine is regulated in many countries.
Check Digit Verification of cas no
The CAS Registry Mumber 53924-03-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,9,2 and 4 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 53924-03:
(7*5)+(6*3)+(5*9)+(4*2)+(3*4)+(2*0)+(1*3)=121
121 % 10 = 1
So 53924-03-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H20N2/c1-2-6-13(7-3-1)16-10-12-11-17-15-9-5-4-8-14(12)15/h4-5,8-9,11,13,16-17H,1-3,6-7,10H2
53924-03-1Relevant articles and documents
Structure-activity relationships of small molecule inhibitors of RAGE-Aβ binding
Ross, Nathan T.,Deane, Rashid,Perry, Sheldon,Miller, Benjamin L.
, p. 7653 - 7658 (2013/08/23)
The Receptor for Advanced Glycation Endproducts ('RAGE') mediates transport of amyloid-β peptide (Aβ) into the brain, and is therefore an important target for the development of therapeutic agents for Alzheimer's disease. We describe structure-activity relationships for inhibition of RAGE-Aβ binding, derived from the analysis of a library of tertiary amides.
Synthesis and Reactions of N-Indol-3-ylmethylalkylamines and Related Compounds
Afsah, El-Sayed M.,Jackson, Anthony H.
, p. 1929 - 1932 (2007/10/02)
A series of new N-indol-3-ylmethylalkylamines (1) have been synthesized in excellent yields via transamination between gramine and the appropriate primary alkylamine.The use of tryptamine and propane-1,3-diamine in the exchange reaction afforded N-indol-3-ylmethyltryptamine (2), and N,N'-bis(indol-3-ylmethyl)propane-1,3-diamine (3) respectively, where as the use of methylamine gave N,N-bis(indol-3-ylmethyl)methylamine (4).The exchange reaction has been extended by the use of amino acids to give N,N-bis(indol-3-ylmethyl)tryptophan (6) and N,N-bis-(indol-3-ylmethyl)glycine (8).The secondary amines (1), (2) and the previously known bis(indol-3-ylmethyl)amine proved to be valuable intermediates for the synthesis of some new compounds related to gramine as well as to other indole alkaloids.
