5393-99-7

Usage

Uses

4,5-diphenyl-1,2,3-Thiadiazole is an antibiotic compound with CYP450 inhibitory properties.

InChI:InChI=1/C14H10N2S/c1-3-7-11(8-4-1)13-14(17-16-15-13)12-9-5-2-6-10-12/h1-10H

Upstream product

• 39269-34-6 4,5-diphenyl-[1,2,3]thiadiazole 2-oxide 
• 19816-85-4 N'-(1,2-diphenylethylidene)-4-methylbenzenesulfonohydrazide 
• 834900-09-3 tosylhydrazone 
• 7732-18-5 water 
• 451-40-1 phenyl benzyl ketone 
• 1567-38-0 1,2-diphenyl-ethanone semicarbazone 
• 3469-17-8 2-diazo-1,2-diphenylethan-1-one 
• 59105-14-5 1,2-diphenyl-ethanone acetylhydrazone 

Downstream Products

• 1884-68-0 tetraphenylthiophene 
• 40757-64-0 4,5-diphenyl-2-(diphenylmethylene)-1,3-dithiole 
• 23181-79-5 2,3,5,6-tetraphenyl-1,4-dithia-2,5-cyclohexadiene 
• 35529-46-5 3,4,5-Triphenylisothiazole 
• 501-65-5 diphenyl acetylene 
• 39269-35-7 4,5-diphenyl-[1,2,3]thiadiazole 1,1,2-trioxide 
• 150398-95-1 (E)-thiokohlensaeure-O-ethyl-S-(1,2-diphenyl-ethenyl)-diester 
• 39269-34-6 4,5-diphenyl-[1,2,3]thiadiazole 2-oxide 
• 65200-71-7 4,5-diphenyl-[1,2,3]thiadiazole 1,1,3-trioxide 
• 54191-80-9 N,N-dimethyl-2,2-diphenylthioacetamide 

Relevant academic research and scientific papers

Rhodium Thiavinyl Carbenes from 1,2,3-Thiadiazoles Enable Modular Synthesis of Multisubstituted Thiophenes

The rhodium-catalyzed transannulation reaction between 1,2,3-thiadiazoles and alkynes, proceeding via intermediacy of the previously unknown Rh thiavinyl carbene, toward a highly efficient and regioselective synthesis of up to fully substituted thiophenes is described.

1,2,3-thiadiazole compounds, compositions and method of anti-thrombotic treatment

Novel 1,2,3-thiadiazole compounds, new and old 1,2,3-thiadiazole compositions and method of anti-thrombotic treatment are systemically administered to a human or animal.

Electrosynthesis of (E)-Ethenyl-O-ethyl-thiocarbonates

Electrochemical reductions of 4-aryl- and 4,5-diaryl-1,2,3-thiadiazols (1-5) in acetonitrile/0,1 M tetraalkylammonium-supporting-electrolyte at Hg-cathodes in the presence of ethylchloroformiate (CAE) yield (E)-S-(2-aryl) ethenyl- and S-(1,2-diaryl)etheny

Synthesis and platelet aggregation inhibitory activity of 4,5-bis(substituted)-1,2,3-thiadiazoles

Routine screening of compounds for inhibition of collagen-induced platelet aggregation in vitro revealed 4,5-bis-(4-methoxyphenyl)-1,2,3-thiadiazole was active and it represents the first example of a 1,2,3-thiadiazole with possible antithrombotic activit

Kinetics and Mechanism of the Reaction of Thionyl Chloride with Substituted Acetophenone Semicarbazones. The Synthesis of 1,2,3-Thiadiazoles

The reaction of thionyl chloride with a series of para-substituted acetophenone semicarbazones, which gives 1,2,3-thiadiazoles, involved an electrophilic attack.The rates correlated with the substituent ?+ constants and gave a Hammett ρ value o

Reaction of Substituted Hydrazones with Thionyl Chloride and Sulfuryl Chloride

Treatment of acetylhydrazones 2, ethoxycarbonylhydrazones 3, p-tolylsulfonylhydrazones 4 or semicarbazones 5 with thionyl chloride leads to the 1,2,3-thiadiazoles 6a-o.Sulfuryl chloride on the other hand accomplishes the transfer of chlorine without incorporating a sulfur atom.The new synthesized 1,2,3-thiadiazoles 6g-o are characterized in detail by spectroscopic methods.