53933-60-1

Basic information

• Product Name: SULINDAC RELATED COMPOUND A (20 MG) (TRANS-SULINDAC)
• Synonyms: trans-Sulindac;Sulindac Related Compound A (20 mg) ((E)-2-{5-Fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid);SULINDAC RELATED COMPOUND A (20 MG) (TRANS-SULINDAC);(E)-(±)-5-fluoro-2-methyl-1-[[4-(methylsulphinyl)phenyl]methylene]-1H-indene-3-acetic acid;5-Fluoro-2-methyl-1-[(E)-[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid;(E)-(1)-5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid;Einecs 258-873-0;Sulindac Related CoMpound A
• CAS NO: 53933-60-1
• Molecular Formula: C₂₀H₁₇FO₃S
• Molecular Weight: 356.4105832
• EINECS: 258-873-0
• Mol File: 53933-60-1.mol

Chemical Properties

• Boiling Point: 581.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.38±0.1 g/cm3(Predicted)
• PKA: 4.26±0.10(Predicted)
• CAS DataBase Reference: SULINDAC RELATED COMPOUND A (20 MG) (TRANS-SULINDAC)(CAS DataBase Reference)
• NIST Chemistry Reference: SULINDAC RELATED COMPOUND A (20 MG) (TRANS-SULINDAC)(53933-60-1)
• EPA Substance Registry System: SULINDAC RELATED COMPOUND A (20 MG) (TRANS-SULINDAC)(53933-60-1)

Safety Data

• Hazardous Substances Data: 53933-60-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
SULINDAC RELATED COMPOUND A (20 MG) (TRANS-SULINDAC) is used as an active pharmaceutical ingredient for the treatment of inflammation and pain relief. It is particularly effective in managing conditions such as arthritis, where it helps to reduce swelling, pain, and stiffness.
Additionally, due to its anti-inflammatory properties, TRANS-SULINDAC may also be used as a potential therapeutic agent for other inflammatory conditions, although further research is needed to confirm its efficacy and safety in these applications.

InChI:InChI=1/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)

Upstream product

• 49627-27-2 5-fluoro-2-methyl-1-(4-methylsulfanylbenzylidene)-3-indenylacetic acid 
• 61812-45-1 sulindac sulfide 

Downstream Products

• 144498-50-0 {6-Fluoro-3-[1-(4-methanesulfinyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-inden-1-yl}-methanol 
• 144498-51-1 6-Fluoro-3-[1-(4-methanesulfinyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-indene-1-carbaldehyde 
• 144498-49-7 6-Fluoro-3-[1-(4-methanesulfonyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-indene-1-carbaldehyde 
• 144498-48-6 {6-Fluoro-3-[1-(4-methanesulfonyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-inden-1-yl}-methanol 
• 41201-75-6 6-Fluoro-3-[1-(4-methanesulfinyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-indene-1-carboxylic acid 

Relevant articles and documents

Catalyst-free visible light-mediated selective oxidation of sulfides into sulfoxides under clean conditions

A facile and efficient visible-light-mediated method for directly converting sulfides into sulfoxides under clean conditions without using any photocatalysts is reported. This method exhibited favourable compatibility with functional groups and afforded a series of sulfoxides with high selectivity and yields. Moreover, in order to shed more light on such a transformation, detailed mechanism studies were carried out both experimentally and theoretically. The readily accessible, low-cost and eco-friendly nature of the developed method will endow it with attractive applications in chemical synthesis.

Sulfoxide and sulfone compounds, as well as selective synthesis method and application thereof

The invention discloses a method for selectively synthesizing a sulfoxide compound shown as a formula (II) and a sulfone compound shown as a formula (III). In a reaction solvent, thioether (I) is usedas a reaction raw material and oxygen as an oxidation reagent, under the catalytic action of visible light and a photosensitive reagent; under the assistance of an additive, when a large-polarity proton-containing additive such as an acid and an alcohol or a solvent or an additive with excellent electron donating ability is used, a sulfoxide compound (II) is selectively generated; and when a small-polarity aprotic additive or a solvent is used, a sulfone compound (III) is selectively generated. The synthesis method has the advantages of easily available and cheap raw materials, simple reaction operation, mild reaction conditions, high yield and excellent functional group tolerance. According to the invention, synthesis and modification of some medicines are realized, and an efficient method for selectively constructing sulfoxide and sulfone compounds is provided for medicinal chemistry research.

Process for the preparation of organic compounds containing a sulfinyl or sulfonyl group

A process for the oxidation of thioethers to sulfoxides or sulfones or for the oxidation of sulfoxides to sulfones by treatment of thioethers or sulfoxides with an oxidizing amount of ε-phthalimidoperhexanoic acid is particularly useful for the preparation of compounds of industrial interest, in particular pharmaceuticals for human or veterinary use.

Lactone compounds for treating patient with precancerous lesions

Substituted lactone compounds are useful in the treatment of precancerous lesions and neoplasms.

Lactone compounds for treating patients with precancerous lesions

Substituted lactone compounds are useful in the treatment of precancerous lesions.

Esters and amides of substituted indenyl acetic acids

Esters and amides of substituted indenyl acetic acids of the formula: n is an integer of at least 2;, Q is a deprotonated residue of polymer or macromolecular structure having a molecular weight of at least about 1000 containing at least two primary and/or secondary amino groups and/or hydroxy groups;, R1 is selected from hydrogen, lower alkyl, or haloalkyl;, R2 is selected from hydrogen or alkyl;, R3 and R4 are one or more members each independently chosen from hydrogen, alkyl, acyloxy, alkoxy, nitro, amino, acylamino, alkylamino, diakylamino, dialkylaminoalkyl, sulfamyl, alkythio, mercapto, hydroxy, hydroxyalkyl, alkylsulfonyl, halogen, cyano, carboxyl, carbalkoxy, carbamido, haloalkyl or cycloalkoxy; and, R5 is selected from alkylsulfenyl, alkylsulfinyl or alkylsulfonyl. are useful in the treatment of colonic polyps.

Indenylidene-3-acetic acid process for preparing indene acetic acids

Process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid by reacting fluorobenzene with an acid halide, to form an indanone, reaction of the indanone with a methylthio (or methylsulfinyl)benzyl compound to form 5-fluoro-2-methyl-1-(p-methylthiobenzyl) or (p-methylsulfinylbenzyl)-indene and reacting said indene with a glyoxylic acid. The invention also relates to intermediates thereof and processes for said intermediates.