61812-45-1

Basic information

• Product Name: 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (E)-
• CAS NO: 61812-45-1
• Molecular Formula: C20H17FO2S
• Molecular Weight: 340.418
• Mol File: 61812-45-1.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (E)-(61812-45-1)
• EPA Substance Registry System: 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (E)-(61812-45-1)

Safety Data

• Hazardous Substances Data: 61812-45-1(Hazardous Substances Data)

Upstream product

• 37794-19-7 6-fluoro-2-methylindanone 
• 146857-81-0 4-methylthiobenzaldehyde 
• 37794-13-1 methyl 5-fluoro-2-methyl-1H-3-indenylacetate 
• 5137-55-3 Aliquat 336 
• 53077-50-2 ethyl 2-(5-fluoro-2-methyl-1H-inden-3-yl)acetate 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 459-57-4 4-fluorobenzaldehyde 
• 22138-73-4 3-(4-fluorophenyl)-2-methylpropanoic acid 
• 22138-72-3 3-(4-fluorophenyl)-2-methylacrylic acid 
• 32004-66-3 5-fluoro-2-methyl-1H-indene-3-acetic acid 

Downstream Products

• 38194-50-2 2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetic acid 
• 53933-60-1 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-3-indenyl acetic acid 
• 38194-50-2 Sulindac 

Relevant articles and documents

Green synthesis method of sulindac

The invention discloses a green synthesis method of sulindac and relates to the technical field of organic synthesis. The method comprises the following steps that: 6-fluoro-2-methyl indanone as a rawmaterial and cyanoacetic acid undergo a Knoevenagel reaction to obtain an intermediate 3, the intermediate 3 and p-methylthiobenzaldehyde undergo a Knoevenagel reaction to obtain an intermediate 4, the intermediate 4 undergoes a hydrolysis decarboxylation reaction to obtain an intermediate 5, and the intermediate 5 undergoes an oxidation reaction to obtain sulindac 1. Compared with an existing synthesis process, the process operation is greatly simplified, the raw material utilization rate and the process environmental protection property are improved, the total yield of sulindac reaches 80%or above, and the purity of sulindac reaches 99% or above.

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