53940-07-1Relevant academic research and scientific papers
Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines
Horley, Neill J.,Beresford, Kenneth J.M.,Chawla, Tarun,McCann, Glen J.P.,Ruparelia, Ketan C.,Gatchie, Linda,Sonawane, Vinay R.,Williams, Ibidapo S.,Tan, Hoon L.,Joshi, Prashant,Bharate, Sonali S.,Kumar, Vikas,Bharate, Sandip B.,Chaudhuri, Bhabatosh
, p. 159 - 174 (2017)
The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k (DMU2105) and 6j (DMU2139) have been identified from two series of synthetic pyridylchalcones. They inh
