5395-94-8

Usage

Common uses

Reagent in organic synthesis
Stabilizer for hydrogen peroxide

Physical appearance

White to off-white crystalline powder

Molecular weight

340.48 g/mol

Solubility

Insoluble in water
Soluble in organic solvents (e.g., ethanol and acetone)

Biological activity

Potential applications in the treatment of certain diseases and conditions

Safety precautions

Can be irritating to the skin, eyes, and respiratory system
Care should be taken to avoid exposure

InChI:InChI=1/C17H20N2S/c1-3-13-9-5-7-11-15(13)18-17(20)19-16-12-8-6-10-14(16)4-2/h5-12H,3-4H2,1-2H3,(H2,18,19,20)

Upstream product

• 578-54-1 ortho-ethylaniline 
• 75-15-0 carbon disulfide 

Downstream Products

• 19241-19-1 1-ethyl-2-isothiocyanatobenzene 

Relevant academic research and scientific papers

Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 μM. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.

Solution and molecular modeling studies on some bivalent metal complexes of higher analogues of biologically active 1,3-diaryl-4, 5, 6-pyrimidinetrione-2-thioxo-5-oxime

Thermodynamic proton-ligand stability constants of 1,3-diethylphenyl-4,5,6- pyrimidinetrione-2-thioxo-5-oxime (and the thermodynamic metal ligand stability constants) with some bivalent metal ions were determined by potentiometric measurements in 75% (v/v) aqueous-dioxan medium at different temperatures ranging from 25°C to 35°C. The acidity and stability constants vary according to the kind of substitution at the 1- and 3- positions of the pyrimidine ring. The order of stability constants is UO22+> Cu2+>Ni2+>Co2+>Zn2+ >Cd2+>Mn2+>Mg2+. The values of Smin (χ2)have also been calculated.. The thermodynamic functions for the stepwise complexation processes are calculated at 25±0.5°C. Molecular modeling studies have also been carried out on the ligand and complexes, the results of which corroborate the experimental findings.