53963-41-0Relevant articles and documents
Diastereoselectivity of Additions to Chiral Carbonyl Oxides
Dussault, Patrick H.,Zope, Umesh R.
, p. 8218 - 8222 (2007/10/02)
The influence of a resident stereocenter on the formation of hydroperoxy acetals from carbonyl oxides is investigated.Addition of either methanol or 2-propanol to 2-phenylpropanal O-oxide proceeds with modest stereoselectivity; addition of a tertiary alco
Reaction of Acetals with Grignard Reagents
Ishikawa, Hiroshi,Mukaiyama, Teruaki,Ikeda, Shigeru
, p. 776 - 780 (2007/10/02)
The reaction of dialkyl acetals derived from α,β-unsaturated aldehydes with Grignard reagents using TiCl4 in THF afforded the cross coupling products, allyl ethers, in high yields.The TiCl4-promoted reaction of alkyl 2,4-dichlorophenyl acetals, synthesized from 3,4-dihydro-2H-pyran or ethyl vinyl ether and 2,4-dichlorophenol, with Grignard reagents in THF at low temperature afforded the corresponding unsymmetrical ethers in high yields.When alkyl 2,4-dichlorophenyl acetals, synthesized from aromatic aldehyde or vinyl ethers and 2,4-dichlorophenol, were treated with Grignard reagents in benzene or toluene at room temperature in the absence of TiCl4, the cross coupling reaction took place and the corresponding ethers were isolated in good yields.
