53965-06-3

Upstream product

• 74879-21-3 2,3-bis(methoxycarbonyl)-1-(3,4-dimethoxyphenyl)-4-hydroxy-6,7-methylenedioxynaphthalene 
• 1621253-41-5 tert-butyl (9-hydroxy-8-oxo-6,8-dihydrofuro[3′,4′:6,7]-naphtho[2,3-d][1,3]dioxol-5-yl)carbonate 
• 1621253-39-1 6-formyl-N,N-dimethylbenzo[d][1,3]dioxole-5-carboxamide 
• 1621253-40-4 7-oxo-5,7-dihydro[1,3]dioxolo[4,5-f]isobenzofuran-5-carbonitrile 
• 1621253-42-6 9-[(tert-butoxycarbonyl)oxy]-6-oxo-6,8-dihydrofuro[3′,4′:6,7]-naphtho[2,3-d][1,3]dioxol-5-yl trifluoromethanesulfonate 

Relevant academic research and scientific papers

An Optimized and General Synthetic Strategy To Prepare Arylnaphthalene Lactone Natural Products from Cyanophthalides

A simple method for the preparation of arylnaphthalene lactone natural products was developed and used to synthesize diphyllin (10), justicidin A (12), cilinaphthalide B (13), taiwanin E (15), chinensinaphthol (16), taiwanin E methyl ether (17), chinensin

A mild, highly selective and remarkably easy procedure for deprotection of aromatic acetates using ammonium acetate as a neutral catalyst in aqueous medium

Ammonium acetate was found to catalyze efficiently the selective deprotection of aromatic acetates in the presence of various sensitive functionalities in aqueous methanol under neutral conditions at room temperature to yield the corresponding phenols in excellent yields. The method has been utilized for deprotection of acetates of several naturally occurring bioactive phenolic compounds and for preparation of venkatasin, a natural coumarino-lignan, from the anticancer compound cleomiscosin A.

Efficient Syntheses of 1-Arylnaphthalene Lignan Lactones and Related Compounds from Cyanohydrins

1-Arylnaphthalene lignan lactones were synthesized in good yields from O-(tert-butyldimethylsilyl)cyanohydrins in two steps based on a conjugate addition-aldol reaction, followed by acid-catalyzed closure to form the naphthalene ring. 4-Hydroxy-1-arylnaph

Arylnaphthalene lignans as novel series of hypolipidemic agents raising high-density lipoprotein level

A series of arylnaphthalene lignans were synthesized and tested for hypolipidemic activity. The most potent compound (4b) (TA-7552) not only reduced serum cholesterol, but also increased high-density lipoproteins cholesterol in rats. The effective dose of

Michael Initiated Ring Closure reactions in natural product synthesis: A concise entry to the podophyllins

A rapid entry towards the Podophyllum lignans is described exemplified by a concise regioselective total synthesis of taiwanin E 5 and chinensinaphthol 6. The approach features a Michael Initiated Ring Closure (MIRC type II) sequence to access the key lig

Potential Isobenzofurans: their Use in the Synthesis of Naturally Occurring 1-Arylnaphthalide Lignans

A three-step synthesis of seven lignans by means of a Diels-Alder reaction followed by selective borane reduction of an aromatic ester is described.