74879-21-3Relevant academic research and scientific papers
Potential Isobenzofurans: their Use in the Synthesis of Naturally Occurring 1-Arylnaphthalide Lignans
Plaumann, Heinz P.,Smith, James G.,Rodrigo, Russell
, p. 354 - 355 (1980)
A three-step synthesis of seven lignans by means of a Diels-Alder reaction followed by selective borane reduction of an aromatic ester is described.
Arylnaphthalene lignans as novel series of hypolipidemic agents raising high-density lipoprotein level
Iwasaki,Kondo,Nishitani,Kuroda,Hirakoso,Ohtani,Takashima
, p. 1701 - 1705 (2007/10/03)
A series of arylnaphthalene lignans were synthesized and tested for hypolipidemic activity. The most potent compound (4b) (TA-7552) not only reduced serum cholesterol, but also increased high-density lipoproteins cholesterol in rats. The effective dose of
Naphthalene derivatives and composition and methods of use, and aldehyde intermediates
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, (2008/06/13)
Naphthalene derivative of the formula: STR1 wherein R1 is hydrogen atom or a lower alkoxycarbonyl and R2 is a lower alkoxycarbonyl, or R1 and R2 are combined together to form a group of the formula: STR2 each of
Alkoxynaphthalene derivatives
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, (2008/06/13)
Naphthalene derivative of the formula: STR1 wherein R1 is hydrogen atom or a lower alkoxycarbonyl and R2 is a lower alkoxycarbonyl, or R1 and R2 are combined together to form a group of the formula: STR2 each of
Hydroxyacetals, phtalans, and isobenzofurans therefrom
Keay, Brian A.,Plaumann, Heinz P.,Rajapaksa, Dayananda,Rodrigo, Russell
, p. 1987 - 1995 (2007/10/02)
A general method for the generation of isobenzofuran intermediates is described.Lithiated aromatic acetals are converted to hydroxyacetals (A) which may be cyclized to isobenzofurans by mild acid treatment through the 1-hydroxyphtalans (B).The isobenzofur
