53966-34-0

Basic information

• Product Name: Floxacrine
• Synonyms: Floxacrine;7-Chloro-3,4-dihydro-10-hydroxy-3-[p-(trifluoromethyl)phenyl]-1,9(2H,10H)-acridinedione;HOE-991
• CAS NO: 53966-34-0
• Molecular Formula: C₂₀H₁₃ClF₃NO₃
• Molecular Weight: 407.774
• Mol File: 53966-34-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 545.3°Cat760mmHg
• Flash Point: 283.6°C
• Appearance: /
• Density: 1.56g/cm³
• Vapor Pressure: 1E-12mmHg at 25°C
• Refractive Index: 1.648
• CAS DataBase Reference: Floxacrine(CAS DataBase Reference)
• NIST Chemistry Reference: Floxacrine(53966-34-0)
• EPA Substance Registry System: Floxacrine(53966-34-0)

Safety Data

• Hazardous Substances Data: 53966-34-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H13ClF3NO3/c21-13-5-6-15-14(9-13)19(27)18-16(25(15)28)7-11(8-17(18)26)10-1-3-12(4-2-10)20(22,23)24/h1-6,9,11,28H,7-8H2

Upstream product

• 80992-93-4 4-(4-trifluoromethylphenyl)but-3-en-2-one 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 55579-69-6 5-<4-(trifluoromethyl)phenyl>-1,3-cyclohexanedione 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 91189-77-4 7-chloro-1,3,4,10-tetrahydro-10-hydroxy-1-(4-morpholinylimino)-3-<4-(trifluoromethyl)phenyl>-9(2H)-acridinone 
• 102192-47-2 7-Chloro-10-hydroxy-1-[(5-phenyl-[1,2,4]triazin-3-yl)-hydrazono]-3-(4-trifluoromethyl-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 91189-76-3 7-Chloro-1-(dimethyl-hydrazono)-10-hydroxy-3-(4-trifluoromethyl-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80092-33-7 7-Chloro-1-[(E)-3-dimethylamino-propylimino]-10-hydroxy-3-(4-trifluoromethyl-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80092-54-2 7-Chloro-1-[(E)-2-diethylamino-ethylimino]-10-hydroxy-3-(4-trifluoromethyl-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80108-17-4 1-{(E)-3-[Bis-(2-hydroxy-ethyl)-amino]-propylimino}-7-chloro-10-hydroxy-3-(4-trifluoromethyl-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 90832-34-1 3-(4-Trifluoromethylphenyl)-7-chloro-10-hydroxy-3,4-dihydroacridine-1,9(2H,10H)-dione 1-(N-methyl-N'-piperazinyl)imine 
• 133929-36-9 9-Chloro-4-(4-trifluoromethyl-phenyl)-4,5-dihydro-3H-1-oxa-2,6-diaza-aceanthrylene 6-oxide 
• 80092-66-6 7-Chloro-1-[(E)-7-diethylamino-heptylimino]-3-(4-trifluoromethyl-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80108-23-2 7-Chloro-1-[(E)-4-diethylamino-1-methyl-butylimino]-3-(4-trifluoromethyl-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80092-69-9 7-Chloro-1-[(E)-3-diethylamino-2,2-dimethyl-propylimino]-3-(4-trifluoromethyl-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80092-67-7 7-Chloro-1-[(E)-4-diethylamino-butylimino]-3-(4-trifluoromethyl-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80092-64-4 7-Chloro-1-[(E)-2-dimethylamino-propylimino]-3-(4-trifluoromethyl-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80092-65-5 7-Chloro-1-[(E)-2-diethylamino-ethylimino]-3-(4-trifluoromethyl-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 

Relevant articles and documents

Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures

To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.

10-Hydroxy-3,4-dihydroacridine-1,9(2H,10H)-diones: a new group of malaricidal and coccidiostatic compounds

2-Nitrobenzaldehydes and 1,3-cyclohexanediones condense in a mixture of hydrocholic acid and glacial acetic acid to 10-hydroxy-3,4-dihydroacridine-1,9(2H,10H)-diones. Many compounds of this group reveal a pronounced coccidiostatic and malaricidal effect i